FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W993927001> ?p ?o ?g. }

• W993927001 abstract "Abstract The present study was designed to identify genomic loci modulating the susceptibility of retinal ganglion cells (RGC) to elevated intraocular pressure (IOP) in the BXD recombinant inbred mouse strain set. IOP was elevated by injecting magnetic microspheres into the anterior chamber and blocking the trabecular meshwork using a handheld magnet to impede drainage. The IOP was then measured over the next 21 days. Only animals with IOP greater than 25 mmHg for two consecutive days or an IOP above 30 mmHg on a single day after microsphere-injection were used in this study. On day 21, mice were sacrificed and the optic nerve was processed for histology. Axons were counted for both the injected and the control eye in 49 BXD strains, totaling 181 normal counts and 191 counts associated with elevated IOP. The axon loss for each strain was calculated and the data were entered into genenetwork.org. The average number of normal axons in the optic nerve across all strains was 54,788 ± 16% (SD), which dropped to 49,545 ± 20% in animals with artificially elevated IOP. Interval mapping demonstrated a relatively similar genome-wide map for both conditions with a suggestive Quantitative Trait Locus (QTL) on proximal Chromosome 3. When the relative axon loss was used to generate a genome-wide interval map, we identified one significant QTL ( p <0.05) on Chromosome 18 between 53.6 and 57 Mb. Within this region, the best candidate gene for modulating axon loss was Aldh7a1 . Immunohistochemistry demonstrated ALDH7A1 expression in mouse RGCs. ALDH7A1 variants were not significantly associated with glaucoma in the NEIGHBORHOOD GWAS dataset, but this enzyme was identified as part of the butanoate pathway previously associated with glaucoma risk. Our results suggest that genomic background influences susceptibility to RGC degeneration and death in an inducible glaucoma model." @default.
• W993927001 created "2016-06-24" @default.
• W993927001 creator A5025281822 @default.
• W993927001 creator A5045113631 @default.
• W993927001 creator A5051524591 @default.
• W993927001 creator A5054191294 @default.
• W993927001 creator A5077663520 @default.
• W993927001 creator A5086641481 @default.
• W993927001 date "2017-11-01" @default.
• W993927001 modified "2023-09-25" @default.
• W993927001 title "Genomic LOCI Modulating Retinal Ganglion Cell Death Following Elevated IOP in the Mouse" @default.
• W993927001 cites W1129919997 @default.
• W993927001 cites W1960721561 @default.
• W993927001 cites W1974273434 @default.
• W993927001 cites W1979464604 @default.
• W993927001 cites W1989399186 @default.
• W993927001 cites W1991677561 @default.
• W993927001 cites W2013859310 @default.
• W993927001 cites W2032124492 @default.
• W993927001 cites W2045269704 @default.
• W993927001 cites W2050065221 @default.
• W993927001 cites W2061404823 @default.
• W993927001 cites W2065969837 @default.
• W993927001 cites W2067341924 @default.
• W993927001 cites W2079224601 @default.
• W993927001 cites W2087647596 @default.
• W993927001 cites W2099955914 @default.
• W993927001 cites W2135114355 @default.
• W993927001 cites W2135930638 @default.
• W993927001 cites W2145908472 @default.
• W993927001 cites W2147122728 @default.
• W993927001 cites W2157890401 @default.
• W993927001 cites W2265638154 @default.
• W993927001 cites W2499240546 @default.
• W993927001 cites W2520667824 @default.
• W993927001 cites W2524796157 @default.
• W993927001 cites W2568000928 @default.
• W993927001 cites W2623499978 @default.
• W993927001 cites W2626606138 @default.
• W993927001 doi "https://doi.org/10.1101/212753" @default.
• W993927001 hasPublicationYear "2017" @default.
• W993927001 type Work @default.
• W993927001 sameAs 993927001 @default.
• W993927001 citedByCount "0" @default.
• W993927001 crossrefType "posted-content" @default.
• W993927001 hasAuthorship W993927001A5025281822 @default.
• W993927001 hasAuthorship W993927001A5045113631 @default.
• W993927001 hasAuthorship W993927001A5051524591 @default.
• W993927001 hasAuthorship W993927001A5054191294 @default.
• W993927001 hasAuthorship W993927001A5077663520 @default.
• W993927001 hasAuthorship W993927001A5086641481 @default.
• W993927001 hasBestOaLocation W9939270011 @default.
• W993927001 hasConcept C104317684 @default.
• W993927001 hasConcept C105702510 @default.
• W993927001 hasConcept C106208931 @default.
• W993927001 hasConcept C118487528 @default.
• W993927001 hasConcept C135763542 @default.
• W993927001 hasConcept C153209595 @default.
• W993927001 hasConcept C169760540 @default.
• W993927001 hasConcept C2776521421 @default.
• W993927001 hasConcept C2777093970 @default.
• W993927001 hasConcept C2777624874 @default.
• W993927001 hasConcept C2778527774 @default.
• W993927001 hasConcept C2779530196 @default.
• W993927001 hasConcept C2780827179 @default.
• W993927001 hasConcept C2780837183 @default.
• W993927001 hasConcept C2781092963 @default.
• W993927001 hasConcept C2781121420 @default.
• W993927001 hasConcept C54355233 @default.
• W993927001 hasConcept C69991583 @default.
• W993927001 hasConcept C71924100 @default.
• W993927001 hasConcept C76725341 @default.
• W993927001 hasConcept C81941488 @default.
• W993927001 hasConcept C84597430 @default.
• W993927001 hasConcept C86803240 @default.
• W993927001 hasConceptScore W993927001C104317684 @default.
• W993927001 hasConceptScore W993927001C105702510 @default.
• W993927001 hasConceptScore W993927001C106208931 @default.
• W993927001 hasConceptScore W993927001C118487528 @default.
• W993927001 hasConceptScore W993927001C135763542 @default.
• W993927001 hasConceptScore W993927001C153209595 @default.
• W993927001 hasConceptScore W993927001C169760540 @default.
• W993927001 hasConceptScore W993927001C2776521421 @default.
• W993927001 hasConceptScore W993927001C2777093970 @default.
• W993927001 hasConceptScore W993927001C2777624874 @default.
• W993927001 hasConceptScore W993927001C2778527774 @default.
• W993927001 hasConceptScore W993927001C2779530196 @default.
• W993927001 hasConceptScore W993927001C2780827179 @default.
• W993927001 hasConceptScore W993927001C2780837183 @default.
• W993927001 hasConceptScore W993927001C2781092963 @default.
• W993927001 hasConceptScore W993927001C2781121420 @default.
• W993927001 hasConceptScore W993927001C54355233 @default.
• W993927001 hasConceptScore W993927001C69991583 @default.
• W993927001 hasConceptScore W993927001C71924100 @default.
• W993927001 hasConceptScore W993927001C76725341 @default.
• W993927001 hasConceptScore W993927001C81941488 @default.
• W993927001 hasConceptScore W993927001C84597430 @default.
• W993927001 hasConceptScore W993927001C86803240 @default.
• W993927001 hasLocation W9939270011 @default.
• W993927001 hasLocation W9939270012 @default.

• next