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- W994383618 abstract "目的研究双自杀基因HSV-tk/CD的体内外旁观者效应.方法在体外将tk/CD阳性的胆管癌QBC939细胞与亲本细胞按不同的比例混合,并与单自杀基因组对照,观察给予前体药物后对混合细胞的生长抑制情况.建立荷瘤裸鼠模型,在瘤体内注入不同数量的tk/CD阳性胆管癌细胞,观察给予前药后的旁观者效应.结果融合基因组在体外产生明显强于单基因组的BSE,tk组的BSE出现较晚,阳性细胞的比例需达到40%,而CD组和融合基因组中,阳性细胞仅占20%时,就可观察到明显的BSE.体内实验也观察到BSE,强度与注入阳性细胞数有关(P＜0.05);本研究没有观察到远处旁观者效应.结论腺病毒介导的双自杀基因HSV-tk/CD在体外和体内均可产生旁观者效应." @default.
- W994383618 created "2016-06-24" @default.
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- W994383618 date "2004-01-01" @default.
- W994383618 modified "2023-09-24" @default.
- W994383618 title "双自杀基因HSV-tk／CD对胆管癌体内体外旁观者效应的研究" @default.
- W994383618 hasPublicationYear "2004" @default.
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