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- W994440605 abstract "目的探讨原发性肾病综合征（PNS）患儿外周血单个核细胞（PBMC）核因子（NF）-κB活性水平及IL-8与发病机制的关系。方法25例PNS患儿取静脉血5ml，分离PBMC，取3管：①管单纯培养（培养组），②管加入IL-1β刺激剂（IL-1β组），③管加入TPCK抑制剂（TPCK组）。各管培养后用ELISA法测核蛋白提取物NF-κB活性及培养上清液的IL-8浓度。并以20例正常儿童为对照。结果PNS患儿和正常儿童IL-1β组NF-κB活性及IL-8浓度最高，TPCK组最低，培养组、IL-1β组及TPCK组3组间的NF-κB活性及IL-8含量比较差异均有显著性（P〈0．05）。PNS患儿的NF-κB活性及IL-8含量均显著高于正常儿童（P〈0．05）。Pearson相关分析显示，PNS患儿NF-κB活性与IL-8含量呈直线正相关。结论NF-κB及IL-8可能在PNS发病机制中起重要作用，NF-κB与IL-8通过其网络调控作用促进PNS的发生发展；通过抑制NF-κB的升高可能有助于预防疾病的发展。" @default.
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- W994440605 date "2006-01-01" @default.
- W994440605 modified "2023-09-22" @default.
- W994440605 title "原发性肾病综合征患儿PBMC NF-κB活性水平与IL-8关系探讨" @default.
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