Matches in SemOpenAlex for { <https://semopenalex.org/work/W99445145> ?p ?o ?g. }
- W99445145 abstract "Abstract Stem cells can be derived from the embryo (embryonic stem cells, ESCs), from adult tissues (adult stem cells, ASCs), and by induction of fibroblasts (induced pluripotent stem cells, iPSs). Ethical problems, immunological rejection, and difficulties in obtaining human tissues limit the use of ESCs in clinical medicine. Induced pluripotent stem cells are difficult to maintain in vitro and carry a greater risk of tumor formation. Furthermore, the complexity of maintenance and propagation is especially difficult in the clinic. Adult stem cells can be isolated from several adult tissues and present the possibility of self-transplantation for the clinical treatment of a variety of human diseases. Recently, several ASCs have been successfully isolated and cultured in vitro, including hematopoietic stem cells (HSCs) , mesenchymal stem cells (MSCs), epidermis stem cells, neural stem cells (NSCs), adipose-derived stem cells (ADSCs), islet stem cells, and germ line stem cells. Human mesenchymal stem cells originate mainly from bone marrow, cord blood, and placenta, but epidermis-derived MSCs have not yet been isolated. We isolated small spindle-shaped cells with strong proliferative potential during the culture of human epidermis cells and designed a medium to isolate and propagate these cells. They resembled MSCs morphologically and demonstrated pluripotency in vivo; thus, we defined these cells as human epidermis-derived mesenchymal stem cell-like pluripotent cells (hEMSCPCs). These hEMSCPCs present a possible new cell resource for tissue engineering and regenerative medicine." @default.
- W99445145 created "2016-06-24" @default.
- W99445145 creator A5002425288 @default.
- W99445145 creator A5006412117 @default.
- W99445145 creator A5009796482 @default.
- W99445145 creator A5027874662 @default.
- W99445145 creator A5028372785 @default.
- W99445145 creator A5029464861 @default.
- W99445145 creator A5038446428 @default.
- W99445145 creator A5042145479 @default.
- W99445145 creator A5048376181 @default.
- W99445145 creator A5050301187 @default.
- W99445145 creator A5051090517 @default.
- W99445145 creator A5052022256 @default.
- W99445145 creator A5052714538 @default.
- W99445145 creator A5054501761 @default.
- W99445145 creator A5059274907 @default.
- W99445145 creator A5062051639 @default.
- W99445145 creator A5070239116 @default.
- W99445145 creator A5078164215 @default.
- W99445145 creator A5078699661 @default.
- W99445145 creator A5085332941 @default.
- W99445145 creator A5088887756 @default.
- W99445145 creator A5089725662 @default.
- W99445145 date "2011-06-08" @default.
- W99445145 modified "2023-09-25" @default.
- W99445145 title "Generation of Human Epidermis-Derived Mesenchymal Stem Cell-like Pluripotent Cells and their reprogramming in mouse chimeras" @default.
- W99445145 cites W1515519882 @default.
- W99445145 cites W1518831632 @default.
- W99445145 cites W1816761971 @default.
- W99445145 cites W1984197757 @default.
- W99445145 cites W2000115558 @default.
- W99445145 cites W2013246689 @default.
- W99445145 cites W2014583210 @default.
- W99445145 cites W2018028722 @default.
- W99445145 cites W2019229253 @default.
- W99445145 cites W2037338370 @default.
- W99445145 cites W2040107040 @default.
- W99445145 cites W2054603329 @default.
- W99445145 cites W2054939637 @default.
- W99445145 cites W2056719211 @default.
- W99445145 cites W2059378220 @default.
- W99445145 cites W2072087485 @default.
- W99445145 cites W2080416062 @default.
- W99445145 cites W2086663462 @default.
- W99445145 cites W2094016500 @default.
- W99445145 cites W2102560467 @default.
- W99445145 cites W2159999899 @default.
- W99445145 cites W2163404991 @default.
- W99445145 cites W2169872175 @default.
- W99445145 doi "https://doi.org/10.1038/npre.2011.6016.1" @default.
- W99445145 hasPublicationYear "2011" @default.
- W99445145 type Work @default.
- W99445145 sameAs 99445145 @default.
- W99445145 citedByCount "1" @default.
- W99445145 countsByYear W994451452012 @default.
- W99445145 crossrefType "journal-article" @default.
- W99445145 hasAuthorship W99445145A5002425288 @default.
- W99445145 hasAuthorship W99445145A5006412117 @default.
- W99445145 hasAuthorship W99445145A5009796482 @default.
- W99445145 hasAuthorship W99445145A5027874662 @default.
- W99445145 hasAuthorship W99445145A5028372785 @default.
- W99445145 hasAuthorship W99445145A5029464861 @default.
- W99445145 hasAuthorship W99445145A5038446428 @default.
- W99445145 hasAuthorship W99445145A5042145479 @default.
- W99445145 hasAuthorship W99445145A5048376181 @default.
- W99445145 hasAuthorship W99445145A5050301187 @default.
- W99445145 hasAuthorship W99445145A5051090517 @default.
- W99445145 hasAuthorship W99445145A5052022256 @default.
- W99445145 hasAuthorship W99445145A5052714538 @default.
- W99445145 hasAuthorship W99445145A5054501761 @default.
- W99445145 hasAuthorship W99445145A5059274907 @default.
- W99445145 hasAuthorship W99445145A5062051639 @default.
- W99445145 hasAuthorship W99445145A5070239116 @default.
- W99445145 hasAuthorship W99445145A5078164215 @default.
- W99445145 hasAuthorship W99445145A5078699661 @default.
- W99445145 hasAuthorship W99445145A5085332941 @default.
- W99445145 hasAuthorship W99445145A5088887756 @default.
- W99445145 hasAuthorship W99445145A5089725662 @default.
- W99445145 hasBestOaLocation W994451451 @default.
- W99445145 hasConcept C104317684 @default.
- W99445145 hasConcept C107459253 @default.
- W99445145 hasConcept C10854531 @default.
- W99445145 hasConcept C109661977 @default.
- W99445145 hasConcept C123012128 @default.
- W99445145 hasConcept C13685319 @default.
- W99445145 hasConcept C138851942 @default.
- W99445145 hasConcept C143441281 @default.
- W99445145 hasConcept C145103041 @default.
- W99445145 hasConcept C1491633281 @default.
- W99445145 hasConcept C18414845 @default.
- W99445145 hasConcept C198826908 @default.
- W99445145 hasConcept C202751555 @default.
- W99445145 hasConcept C20875687 @default.
- W99445145 hasConcept C28328180 @default.
- W99445145 hasConcept C54355233 @default.
- W99445145 hasConcept C77255625 @default.
- W99445145 hasConcept C86803240 @default.
- W99445145 hasConcept C95444343 @default.
- W99445145 hasConceptScore W99445145C104317684 @default.