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- W994625307 abstract "目的为明确低剂量重组人生长激素(growth hormone,GH)和低热量营 养对患者术后的代谢作用,我们对18例择期胃或结肠切除术后患者进行了安慰剂对照的随机 、双盲临床研究.方法患者每日经肠外营养给以的热量为20cal/k g,蛋白量为1g/kg.术后第1周每日注射低剂量GH或安慰剂.研究计划经协和医院学术委员会批准.结果对照组9例患者体重下降3.3 kg(为术前体重的5.9% ),8天内总的氮丢失为32.6±4.2g.GH组的体重下降(1.3kg)和氮丢失(7.1±3.1g) 均 明显少于对照组(P＜0.001).氮动力研究表明GH的促合成代谢效应与蛋 白合成增加有关,氨基酸流动变化研究表明GH治疗组患者其前臂肌肉对氨基酸氮的摄入 增强.人体组成分析显示,GH组患者虽经受大手术,但其无脂肉质仍得以维持. 结论 GH和低卡营养支持可调节术后分解代谢.今后应在更大人群中对上述代 谢和生理效应进行有对照的随机、双盲临床研究,以了解这一疗法对减少外科患者术后并发症、死亡率和住院时间的影响." @default.
- W994625307 created "2016-06-24" @default.
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- W994625307 date "2002-01-01" @default.
- W994625307 modified "2023-09-24" @default.
- W994625307 title "重组人生长激素和低热卡营养支持对减少术后患者蛋白分解代谢的作用（随机、对照、双盲临床研究）" @default.
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