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- W995201006 abstract "The Complement system consists of more than twenty components and regulatory plasma proteins involved in both specific (immune) and natural host defense. Upon activation, the classical and the alternative pathways of Complement, both form specific proteolytic complexes named “C3 convertases” that cleave C3 and generate the major cleavage fragment C3b. The classical pathway is often activated after binding of C1 to an IgG or IgM-antigen complex; in contrast, activation of the alternative pathway by activating cell surfaces is dependent on their chemical composition and may occur in the absence of antibody. C3b binds to activating immune complexes or cell surfaces and may interact with the alternative pathway proteins B, D and P to form the amplification C3 convertase that augments C3 cleavage and generation/deposition of C3b. Accumulation of C3b molecules on the target surface changes C3 convertases to C5 convertases and activates the effector sequence C5–C9 generating leukocyte attracting, vasoactive and cytolytic activities of activated Complement. The molecular mechanisms of activation and regulation of the classical and alternative pathway have recently been reviewed in detail1,2." @default.
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- W995201006 date "1984-01-01" @default.
- W995201006 modified "2023-09-23" @default.
- W995201006 title "Interactions between the Alternative Complement Pathway and Proteases of the Coagulation System" @default.
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- W995201006 doi "https://doi.org/10.1007/978-1-4615-9355-3_19" @default.
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