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- W99588384 abstract "The effects of alpha-chlorohydrin on the epididymides of rat and gerbil (Meriones hurrianae Jerdon) were reinvestigated. 60 adult and 20 35-day-old male rats received orally 25 mg/kg/day for 24 days while 60 gerbils received 20 mg/kg/day for 50 days. 1 mg of testosterone propionate was administered simultaneously to some of the animals for the last 10 days of treatment. The animals were sacrificed 24 hours after the final dose of alpha-chlorohydrin. Alpha-chlorohydrin caused a loss in epididymal weights and testosterone stimulated the growth of epididymides. Epididymal epithelium cell height and the stereocilia remained normal in all treated animals and the lumen was devoid of spermatozoa. The original investigation indicated that alpha-chlorohydrine produced lesions in the caput epididymides characterized by sloughing of the epithelium which lead to obstruction of the sperm passage. However this investigation indicated that alpha-chlorhydrin caused high selectivity of lesions in the seminiferous tubules." @default.
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- W99588384 date "1975-09-01" @default.
- W99588384 modified "2023-10-18" @default.
- W99588384 title "A reinvestigation of the effects of alpha-chlorohydrin on the epididymides of rat & gerbil (Meriones hurrianae Jerdon)." @default.
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