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- W99590969 abstract "Recently, the ligand of the myeloid surface receptor encoded by the proto- oncogene c-kit (Yarden et al. 1987; Zsebo et al. 1990b) was identified to be a novel hematopoietic growth factor that stimulates primitive progenitor cells (Zsebo et al. 1990a,c). This stem cell factor (SCF) is a multipotent hematopoietic colony-stimulating factor acting on early progenitors of the different hematopoietic lineages. The complementary (c)DNA for human SCF has been cloned and expressed in mammalian cells, and the recombinant factor purified to homogeneity (Zsebo et al. 1990c; Martin et al. 1990). Whereas SCF itself has only a low capacity for inducing colony formation in progenitor assays in vitro [colony-forming unit-granulocyte, macrophage (CFU-GM), burst-forming unit-erythrocyte (BFU-E), CFU- granulocyte, erythrocyte, macrophage, megakaryocyte (CFU-GEMM), and CFU-lymphocyte (CFU-L)] on normal bone marrow cells, it has strong synergistic activities with other factors. It synergizes with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM- CSF), and interleukin-3 (IL-3) in myelopoiesis (McNiece et al. 1991a), with erythropoietin (EPO) in erythropoiesis (McNiece et al. 1991a), with IL-6 in megakaryopoiesis, with IL-7 in lymphopoiesis (McNiece et al. 1991b), and with IL-3 in mast cell growth (Medlock et al. 1990). In this study we investigated the mitogenic potential of SCF alone or in synergy with other factors on myeloid leukemia lines as well as the expression of its specific receptors on the cell surface." @default.
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- W99590969 date "1993-01-01" @default.
- W99590969 modified "2023-09-25" @default.
- W99590969 title "Human Stem Cell Factor Is a Growth Factor for Myeloid Leukemia Cells" @default.
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- W99590969 doi "https://doi.org/10.1007/978-3-642-84895-7_29" @default.
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