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- W995940908 abstract "目的：观察复方黄芪首乌合剂对代谢综合征大鼠早期足细胞损伤的保护作用及其机制。方法：采用高糖高脂饲料喂养法建立实验性代谢综合征大鼠模型，以复方黄芪首鸟合剂（高、中、低剂量组）灌胃治疗，8周末收集尿标本检测24h尿蛋白（24hPro）、尿微量白蛋白（MA）和尿白蛋白肌酐比值（albumintocreatinineratio，ACR）；免疫组织化学法检测肾皮质Nephrin和Podocin的蛋白表迭；逆转录一聚合酶链反应（1iT—PCR）检测肾皮质Nephrin和PodocinmRNA的表达；电镜下观察肾脏基底膜和足细胞的变化。结果：造模大鼠24hPro、MA和ACR较正常对照组明显增加（P〈0．01）；肾小球基底膜显著增厚，足细胞与对照组大鼠比较明显减少，足突排列紊乱，足突融合；肾皮质Podocin、Nephrin蛋白和mRNA表达明显低于正常对’照组（P〈0．05）。经复方黄芪首乌合剂治疗8周后，24hPro、MA、ACR均明显减少（P〈0．05）；肾小球基底膜病变减轻，细胞外基质增多减轻，足细胞数目增多，足细胞融合减轻；肾皮质Podocin、Nephrin蛋白和mRNA表达分别较模型组显著增加（P〈0．05）。结论：复方黄芪首鸟合荆对代谢综合征大鼠肾脏足细胞损伤有保护作用，其作用机制可能与其参与调节代谢综合征大鼠肾组织Nephrin和Podocin的蛋白和mRNA表达有关。" @default.
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- W995940908 date "2014-01-01" @default.
- W995940908 modified "2023-09-24" @default.
- W995940908 title "复方黄芪首乌合剂对代谢综合征大鼠肾组织 Nephrin和 Podocin 的调节作用" @default.
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