Matches in SemOpenAlex for { <https://semopenalex.org/work/W99614518> ?p ?o ?g. }
- W99614518 abstract "Mitotic motors have gained considerable interest as anticancer targets given their often essential functions during mitosis. Furthermore, mitotic motors are thought to represent ideal targets because their functions are believed to be confined to mitosis; thus, only rapidly dividing cells would be susceptible to inhibitors of mitotic motors. The work presented herein challenges the concept of mitotic motors as specific targets of dividing cells by exploring the interphase function of three mitotic motors Kid, Eg5, and MKLP1. Our results demonstrate that all three motors associate with the nucleolus and with the ribosomal subunits. Furthermore, it is demonstrated Eg5 functions to increase the processivity of the ribosome, the first cellular factor to be characterized with that property. Additionally, as loss of Kid results in an increase in focal adhesion proteins throughout the cell and increased protein synthesis in its absence, our data are consistent with a role for Kid in mRNA silencing and transport of mRNAs for site-specific translation. Also, evidence is presented that suggests a role for Kid in ribosome biogenesis and/or ribosomal function, similar to nucleophosmin. Finally, both Kid and Eg5 participate in stress granule dynamics, with Kid and Eg5 functioning in stress granule formation, and Eg5 participating in stress granule coalescence, transport and dissolution. Collectively these findings demonstrate diverse interphase functions for these mitotic motors in nearly all phases of the ribosome's life cycle. These studies not only call into question the potential safety of mitotic motor inhibitors for the treatment of cancer, but also open a new avenue of exploring polypeptide synthesis." @default.
- W99614518 created "2016-06-24" @default.
- W99614518 creator A5070107661 @default.
- W99614518 date "2010-12-09" @default.
- W99614518 modified "2023-09-27" @default.
- W99614518 title "DISCOVERY AND CHARACTERIZATION OF THE INTERPHASE FUNCTION OF MITOTIC MOTORS IN PROTEIN SYNTHESIS" @default.
- W99614518 cites W1001283980 @default.
- W99614518 cites W1129917650 @default.
- W99614518 cites W1524814945 @default.
- W99614518 cites W1538479947 @default.
- W99614518 cites W1592629267 @default.
- W99614518 cites W1593946427 @default.
- W99614518 cites W1600597578 @default.
- W99614518 cites W1849819493 @default.
- W99614518 cites W1895195120 @default.
- W99614518 cites W1898622332 @default.
- W99614518 cites W1928939008 @default.
- W99614518 cites W1965854549 @default.
- W99614518 cites W1966521400 @default.
- W99614518 cites W1967946050 @default.
- W99614518 cites W1969264016 @default.
- W99614518 cites W1969368931 @default.
- W99614518 cites W1969839166 @default.
- W99614518 cites W1972400547 @default.
- W99614518 cites W1972974768 @default.
- W99614518 cites W1974045468 @default.
- W99614518 cites W1977666960 @default.
- W99614518 cites W1979086700 @default.
- W99614518 cites W1982610985 @default.
- W99614518 cites W1982871123 @default.
- W99614518 cites W1983365254 @default.
- W99614518 cites W1983788160 @default.
- W99614518 cites W1986707487 @default.
- W99614518 cites W1988678729 @default.
- W99614518 cites W1990584803 @default.
- W99614518 cites W1992169314 @default.
- W99614518 cites W1993969571 @default.
- W99614518 cites W1999440327 @default.
- W99614518 cites W1999782687 @default.
- W99614518 cites W2002928823 @default.
- W99614518 cites W2012966977 @default.
- W99614518 cites W2015558511 @default.
- W99614518 cites W2018342523 @default.
- W99614518 cites W2019366492 @default.
- W99614518 cites W2020011192 @default.
- W99614518 cites W2022175724 @default.
- W99614518 cites W2027577851 @default.
- W99614518 cites W2029178312 @default.
- W99614518 cites W2034398269 @default.
- W99614518 cites W2034885685 @default.
- W99614518 cites W2035733505 @default.
- W99614518 cites W2038169765 @default.
- W99614518 cites W2040871004 @default.
- W99614518 cites W2041212846 @default.
- W99614518 cites W2042539754 @default.
- W99614518 cites W2044099960 @default.
- W99614518 cites W2044561443 @default.
- W99614518 cites W2047024375 @default.
- W99614518 cites W2047300347 @default.
- W99614518 cites W2047585833 @default.
- W99614518 cites W2048478901 @default.
- W99614518 cites W2049591500 @default.
- W99614518 cites W2049883153 @default.
- W99614518 cites W2052137498 @default.
- W99614518 cites W2052453216 @default.
- W99614518 cites W2052997718 @default.
- W99614518 cites W2055374398 @default.
- W99614518 cites W2058170261 @default.
- W99614518 cites W2060631712 @default.
- W99614518 cites W2060717672 @default.
- W99614518 cites W2062417955 @default.
- W99614518 cites W2063760089 @default.
- W99614518 cites W2067978209 @default.
- W99614518 cites W2071672251 @default.
- W99614518 cites W2073257161 @default.
- W99614518 cites W2073400376 @default.
- W99614518 cites W2076104235 @default.
- W99614518 cites W2077203424 @default.
- W99614518 cites W2077416416 @default.
- W99614518 cites W2078766179 @default.
- W99614518 cites W2083199196 @default.
- W99614518 cites W2090109154 @default.
- W99614518 cites W2093139273 @default.
- W99614518 cites W2093549030 @default.
- W99614518 cites W2101079366 @default.
- W99614518 cites W2105842486 @default.
- W99614518 cites W2110078785 @default.
- W99614518 cites W2111346201 @default.
- W99614518 cites W2113433319 @default.
- W99614518 cites W2114025779 @default.
- W99614518 cites W2115777487 @default.
- W99614518 cites W2118093120 @default.
- W99614518 cites W2120810427 @default.
- W99614518 cites W2121879721 @default.
- W99614518 cites W2124595210 @default.
- W99614518 cites W2125306062 @default.
- W99614518 cites W2125320515 @default.
- W99614518 cites W2128350011 @default.
- W99614518 cites W2129368032 @default.
- W99614518 cites W2129411164 @default.