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- W99617079 endingPage "508" @default.
- W99617079 startingPage "471" @default.
- W99617079 abstract "Chemotherapy-induced peripheral neuropathy (CIPN) is common in patients receiving anticancer treatment and can affect survivability and long-term quality of life of the patient following treatment. The symptoms of CIPN primarily include abnormal sensory discrimination of touch, vibration, thermal information, and pain. There is currently a paucity of pharmacological agents to prevent or treat CIPN. The lack of efficacious therapeutics is due, at least in part, to an incomplete understanding of the mechanisms by which chemotherapies alter the sensitivity of sensory neurons. Although the clinical presentation of CIPN can be similar with the various classes of chemotherapeutic agents, there are subtle differences, suggesting that each class of drugs might induce neuropathy via different mechanisms. Multiple mechanisms have been proposed to underlie the development and maintenance of neuropathy; however, most pharmacological agents generated from preclinical experiments have failed to alleviate the symptoms of CIPN in the clinic. Further research is necessary to identify the specific mechanisms by which each class of chemotherapeutics induces neuropathy." @default.
- W99617079 created "2016-06-24" @default.
- W99617079 creator A5065178270 @default.
- W99617079 date "2015-01-01" @default.
- W99617079 modified "2023-10-14" @default.
- W99617079 title "Chemotherapy-Induced Peripheral Neuropathy" @default.
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