Matches in SemOpenAlex for { <https://semopenalex.org/work/W996210522> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W996210522 abstract "Previous research in Arginase II ko (ArgII) mice have shown that these animals have higher arginine (Arg) fluxes than their WT control littermates. This led us to hypothesize that a substantial catabolism of arginine occurs before the arginine released during protein turnover enters the general circulation. To test this hypothesis, the fluxes of arginine (after correcting for the contribution of ‘de novo' arginine synthesis) and phenylalanine were determined in ArgII and WT mice after saline (control) or i.v. LPS challenge utilizing stable isotopes. Arginine flux was greater in ArgII mice (P < 0.01) than in WT animals and LPS reduced (P < 0.01) the flux of Arg and Phe in both genotypes. The Arg/Phe flux ratio was greater (P 0.001) in ArgII (1.16±0.15) than in WT mice (0.93±0.07), demonstrating that ~20% of the Arg released during protein turnover disappeared under basal (saline) conditions due to hydrolysis by arginase II. After LPS challenge, these ratios decreased to 0.96±0.06 (ArgII) and 0.74±0.06 (WT), indicating that during endotoxemia there is an additional ~20% increase in the catabolism of Arg before it enters the circulating pool. Although the precise mechanism still remains to be elucidated, arginase I is likely responsible for these observations during LPS challenge due to the magnitude of arginine disappearance. These novel observations explain the arginine depletion that occurs during sepsis and offer new targets to increase arginine availability." @default.
- W996210522 created "2016-06-24" @default.
- W996210522 creator A5000830148 @default.
- W996210522 creator A5022533714 @default.
- W996210522 date "2015-04-01" @default.
- W996210522 modified "2023-09-27" @default.
- W996210522 title "Arginine disposal in health and endotoxemia" @default.
- W996210522 doi "https://doi.org/10.1096/fasebj.29.1_supplement.742.14" @default.
- W996210522 hasPublicationYear "2015" @default.
- W996210522 type Work @default.
- W996210522 sameAs 996210522 @default.
- W996210522 citedByCount "0" @default.
- W996210522 crossrefType "journal-article" @default.
- W996210522 hasAuthorship W996210522A5000830148 @default.
- W996210522 hasAuthorship W996210522A5022533714 @default.
- W996210522 hasConcept C126322002 @default.
- W996210522 hasConcept C134018914 @default.
- W996210522 hasConcept C164007495 @default.
- W996210522 hasConcept C178790620 @default.
- W996210522 hasConcept C185592680 @default.
- W996210522 hasConcept C195580219 @default.
- W996210522 hasConcept C197683979 @default.
- W996210522 hasConcept C2776796294 @default.
- W996210522 hasConcept C2777397205 @default.
- W996210522 hasConcept C2777468819 @default.
- W996210522 hasConcept C3675279 @default.
- W996210522 hasConcept C515207424 @default.
- W996210522 hasConcept C55493867 @default.
- W996210522 hasConcept C62231903 @default.
- W996210522 hasConcept C68709404 @default.
- W996210522 hasConcept C71924100 @default.
- W996210522 hasConcept C86803240 @default.
- W996210522 hasConcept C96942376 @default.
- W996210522 hasConceptScore W996210522C126322002 @default.
- W996210522 hasConceptScore W996210522C134018914 @default.
- W996210522 hasConceptScore W996210522C164007495 @default.
- W996210522 hasConceptScore W996210522C178790620 @default.
- W996210522 hasConceptScore W996210522C185592680 @default.
- W996210522 hasConceptScore W996210522C195580219 @default.
- W996210522 hasConceptScore W996210522C197683979 @default.
- W996210522 hasConceptScore W996210522C2776796294 @default.
- W996210522 hasConceptScore W996210522C2777397205 @default.
- W996210522 hasConceptScore W996210522C2777468819 @default.
- W996210522 hasConceptScore W996210522C3675279 @default.
- W996210522 hasConceptScore W996210522C515207424 @default.
- W996210522 hasConceptScore W996210522C55493867 @default.
- W996210522 hasConceptScore W996210522C62231903 @default.
- W996210522 hasConceptScore W996210522C68709404 @default.
- W996210522 hasConceptScore W996210522C71924100 @default.
- W996210522 hasConceptScore W996210522C86803240 @default.
- W996210522 hasConceptScore W996210522C96942376 @default.
- W996210522 hasIssue "S1" @default.
- W996210522 hasLocation W9962105221 @default.
- W996210522 hasOpenAccess W996210522 @default.
- W996210522 hasPrimaryLocation W9962105221 @default.
- W996210522 hasRelatedWork W1496506740 @default.
- W996210522 hasRelatedWork W1620181499 @default.
- W996210522 hasRelatedWork W1676809070 @default.
- W996210522 hasRelatedWork W1979955118 @default.
- W996210522 hasRelatedWork W2045502634 @default.
- W996210522 hasRelatedWork W2131845465 @default.
- W996210522 hasRelatedWork W2136288217 @default.
- W996210522 hasRelatedWork W2315069809 @default.
- W996210522 hasRelatedWork W996210522 @default.
- W996210522 hasRelatedWork W2168702221 @default.
- W996210522 hasVolume "29" @default.
- W996210522 isParatext "false" @default.
- W996210522 isRetracted "false" @default.
- W996210522 magId "996210522" @default.
- W996210522 workType "article" @default.