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- W996386937 abstract "The growth inhibition of Drosophila melanogaster was caused by azadirachtin, a botanical insecticidal limonoids component isolated from Azadirachta. It was investigated that the cell toxicological mechanism prevented insect’s growth and a new insecticidal target was found. The larvae of D. melanogaster fed on the diet contained 0.5, 1.0,2.0,3.0,5.0 mg/kg of azadirachtin in the laboratory, and statistics proved the larvae growth. The apoptosis of D. melanogaster larvae was investigated through fluorescence microscopy. Results showed that azadirachtin under the tested 0.5,1.0,2.0,3.0,5.0 mg/kg concentration obviously inhibited the growth of D. melanogaster larvae. After 5 d being treated with 1~5 mg/kg of azadirachtin, the average weight changed into 1.13~0.38 mg per larva,and the larval developmental period lasted 5.17~12.33 d from 1.41 mg per larva and 4.50 d in control respectively. The growth inhibition rate was 19.86%~73.05%. Some tested larvae delayed pupation, even permanently stayed in larval stage till to die. There were many malformation pupae and adults and the emergence rate of pupae emergence rate decreased to 63.33% - 1.67% while 95% in control , the eggs laid per female decreased to 29.67 - 4.33 while 57.33 in control, respectively. The results showed that apoptosis could be rapidly and reliably visualized in different living D. melanogaster embryos after treatment with 0.5 mg/kg and 2.0 mg/kg of azadirachtin using the vital dyes acridine orange by means of fluorescence microscopy. The peak of apoptosis obviously delayed and duration of apoptosis peak shortened. It is concluded that azadirachtin may inhibit the growth of D. melanogaster by induction of apoptosis,which may be a putative mechanism of insect growth inhibition caused by azadirachtin." @default.
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- W996386937 date "2009-01-01" @default.
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- W996386937 title "Azadirachtin may inhibit Drosophila melanogaster's growth by apoptosis interference." @default.
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