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- W9965294 abstract "Although effective deep brain stimulation of the subthalamic nucleus (STN-DBS) is reported in G2019S leucine-rich repeat kinase 2 (LRRK2) parkinsonism, response to surgery in other LRRK2 mutations has not been previously reported. We present an affected individual from the Lincolnshire pedigree (Y1699C), on whom bilateral STN-DBS was performed to control severe motor fluctuations and dyskinesias. He showed a marked improvement in Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores in the on and off states, sustained for more than three years. Bilateral STN-DBS in LRRK2-parkinsonism with the Y1699C mutation can be as effective as in sporadic PD." @default.
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- W9965294 date "2012-01-01" @default.
- W9965294 modified "2023-09-26" @default.
- W9965294 title "Sustained Response to Deep Brain Stimulation in LRRK2 Parkinsonism with the Y1699C Mutation" @default.
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- W9965294 doi "https://doi.org/10.3233/jpd-012121" @default.
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