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- W996628219 abstract "Publisher Summary Several independent lines of evidence implicate the neostriatum in programming of sequences of actions; sequential movements are disturbed in parkinsonian patients, as evidenced by slowing of movements when they are performed as a part of a sequence. Cools et al. have shown that after bilateral injections of haloperidol into the caudate nucleus, cats walking on a treadmill show a deficit in the capacity to “program the serial ordering of non exteroceptively directed behavior.” In primates, single unit recordings from the putamen have revealed the existence of neurones that are activated prior to the onset of actions, when they are performed as a part of a sequence, but not when the same actions are performed outside of the sequence. In the following sections, a model is defined, based on a selection from present knowledge of the physiology of the component neurones of the striatum and the anatomy of their interconnections. The responses of the model neurones to direct current injections are described in the chapter. The neurones then are connected into a simple network. It will be shown that the network is able to generate sequences of activity patterns in response to a sustained input. The temporal characteristics of the sequences the model is able to produce will then be discussed in relation to the temporal features of the sequential behaviors in which the neostriatum is implicated." @default.
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- W996628219 title "Chapter 21 The corticostriatal system on computer simulation: an intermediate mechanism for sequencing of actions" @default.
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- W996628219 doi "https://doi.org/10.1016/s0079-6123(08)61355-2" @default.
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