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- W99682467 abstract "肝细胞广泛坏死是重型病毒性肝炎的基本病理特征。目前认为由细胞毒性Ｔ淋巴细胞 (Ｃｙｔｏｔｏｘｉｃ ｉｔｙＬｙｍｐｈｏｃｙｔｅ ,ＣＴＬ)介导的细胞毒作用是导致肝细胞坏死的主要免疫机理 ,在此基础上继发的肠源性内毒素血症 ,激活肝内外单核巨噬细胞释放以肿瘤坏死因子α(ＴｕｍｏｒＮｅｃｒｏｓｉｓＦａｃｔｏｒα ,ＴＮＦ -α)为中心的各种细胞因子 ,将进一步加重肝细胞坏死。近年来发现粘附分子 ,特别是细胞间粘附分子 - 1(ＩｎｔｅｒｃｅｌｌｕｌａｒＡｄｈｅｓｉｏｎＭｏｌｅｃｕｌｅ - 1,ＩＣＡＭ - 1)与其配基淋巴细胞功能相关抗原 - 1(ＬｙｍｐｈｏｃｙｔｅＦｕｎｃ ｔｉｏｎＡｓｓｏｃｉａ" @default.
- W99682467 created "2016-06-24" @default.
- W99682467 creator A5022653999 @default.
- W99682467 date "2000-01-01" @default.
- W99682467 modified "2023-09-23" @default.
- W99682467 title "阻断ICAM—1与LFA—1介导的细胞间粘附：治疗肝细胞坏死的新战略" @default.
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