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- W996832828 abstract "This chapter discusses identification of bacterial virulence factors and the five stages of pathogenicity. The identification of bacterial virulence factors involves fulfillment of molecular Koch's postulates, which state that, the virulence factor should be made by all pathogenic isolates. When considering molecular Koch's postulates, it should be remembered that the outcome will depend upon the type of system used to analyze the virulence phenotype, such that findings from studies with tissue culture cells may not be reflected by those with whole animal systems. Furthermore, in order to cause disease a bacterial pathogen must fulfill the following five stages of pathogenicity: (1) adhere to host tissues, (2) invade host tissues (usually), (3) multiply in host tissues, (4) evade host defenses, and (5) cause damage. The pathogen continually monitors its environment and produces virulence factors according to the signals it receives. There is also a host contribution to the process, such that genetic differences between individuals will make one host environment differ from another and affect the interactions, and signals that occur between the pathogen and its environment." @default.
- W996832828 created "2016-06-24" @default.
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- W996832828 date "1998-01-01" @default.
- W996832828 modified "2023-09-27" @default.
- W996832828 title "4.1 Introduction" @default.
- W996832828 doi "https://doi.org/10.1016/s0580-9517(08)70270-8" @default.
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