Matches in SemOpenAlex for { <https://semopenalex.org/work/W99683634> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W99683634 abstract "Inhibitors and methyl donor substrates for BHMT were used to study the role of this enzyme in regulating tHcy. Fasted mice were given an intraperitoneal injection of S-(delta-carboxybutyl)-DL-homocysteine (CBHcy; 1 mg), a specific and potent inhibitor of BHMT, and their tHcy and hepatic BHMT protein and activity levels were monitored over a 24 h period. Compared to saline-injected control mice, at 2 h post-injection the CBHcy-treated mice had 87% lower hepatic BHMT activity and a 3.7-fold increase (11.1 vs. 3.0 uM) in tHcy; effects that lasted nearly 8 h but returned to normal by 24 h. The level of hepatic BHMT protein remained constant over the 24 h period, independent of treatment. Two h after injecting the sulfoxide derivative of CBHcy (10 mg) into fasted mice there was a modest reduction of hepatic BHMT activity and a 1.9-fold increase in tHcy. When given an injection of Met (3 mg) or Met plus CBHcy (1 mg), post-Met load tHcy levels were 3.2-fold higher (128 vs. 40 uM) at 2 h post-injection in the mice given CBHcy. CBHcy does not inhibit folate-dependent methionine synthase, or pyridoxal phosphate-dependent cystathionine synthase. Like betaine, dimethylsulfoniopropionate was an effective tHcy-lowering agent when given with a Met load. These studies are the first to show that transient inhibition of BHMT in vivo causes transient hyperhomocysteinemia, and that dimethylsulfoniopropionate can reduce the post-Met load rise in tHcy. Supported by NIDDK (DK52501) and IL ARS (50–352) to TAG, and grants from the Czech Academy of Sciences (A4055302) and Research Project (Z40550506) to JJ." @default.
- W99683634 created "2016-06-24" @default.
- W99683634 creator A5004481123 @default.
- W99683634 creator A5022260308 @default.
- W99683634 creator A5084007836 @default.
- W99683634 creator A5090217733 @default.
- W99683634 date "2006-03-01" @default.
- W99683634 modified "2023-10-16" @default.
- W99683634 title "The role of betaine‐homocysteine S‐methyltransferase (BHMT) in the regulation of plasma total homocysteine (tHcy)" @default.
- W99683634 doi "https://doi.org/10.1096/fasebj.20.5.a859-c" @default.
- W99683634 hasPublicationYear "2006" @default.
- W99683634 type Work @default.
- W99683634 sameAs 99683634 @default.
- W99683634 citedByCount "0" @default.
- W99683634 crossrefType "journal-article" @default.
- W99683634 hasAuthorship W99683634A5004481123 @default.
- W99683634 hasAuthorship W99683634A5022260308 @default.
- W99683634 hasAuthorship W99683634A5084007836 @default.
- W99683634 hasAuthorship W99683634A5090217733 @default.
- W99683634 hasConcept C104317684 @default.
- W99683634 hasConcept C126322002 @default.
- W99683634 hasConcept C134018914 @default.
- W99683634 hasConcept C16525657 @default.
- W99683634 hasConcept C185592680 @default.
- W99683634 hasConcept C2776523773 @default.
- W99683634 hasConcept C2777090595 @default.
- W99683634 hasConcept C2777248517 @default.
- W99683634 hasConcept C2780912031 @default.
- W99683634 hasConcept C33288867 @default.
- W99683634 hasConcept C515207424 @default.
- W99683634 hasConcept C55493867 @default.
- W99683634 hasConcept C71924100 @default.
- W99683634 hasConcept C80315684 @default.
- W99683634 hasConcept C91965660 @default.
- W99683634 hasConcept C98274493 @default.
- W99683634 hasConceptScore W99683634C104317684 @default.
- W99683634 hasConceptScore W99683634C126322002 @default.
- W99683634 hasConceptScore W99683634C134018914 @default.
- W99683634 hasConceptScore W99683634C16525657 @default.
- W99683634 hasConceptScore W99683634C185592680 @default.
- W99683634 hasConceptScore W99683634C2776523773 @default.
- W99683634 hasConceptScore W99683634C2777090595 @default.
- W99683634 hasConceptScore W99683634C2777248517 @default.
- W99683634 hasConceptScore W99683634C2780912031 @default.
- W99683634 hasConceptScore W99683634C33288867 @default.
- W99683634 hasConceptScore W99683634C515207424 @default.
- W99683634 hasConceptScore W99683634C55493867 @default.
- W99683634 hasConceptScore W99683634C71924100 @default.
- W99683634 hasConceptScore W99683634C80315684 @default.
- W99683634 hasConceptScore W99683634C91965660 @default.
- W99683634 hasConceptScore W99683634C98274493 @default.
- W99683634 hasFunder F4320322482 @default.
- W99683634 hasFunder F4320337357 @default.
- W99683634 hasIssue "5" @default.
- W99683634 hasLocation W996836341 @default.
- W99683634 hasOpenAccess W99683634 @default.
- W99683634 hasPrimaryLocation W996836341 @default.
- W99683634 hasRelatedWork W1968616287 @default.
- W99683634 hasRelatedWork W1990657432 @default.
- W99683634 hasRelatedWork W2080049485 @default.
- W99683634 hasRelatedWork W2084667407 @default.
- W99683634 hasRelatedWork W2097844879 @default.
- W99683634 hasRelatedWork W2127981970 @default.
- W99683634 hasRelatedWork W3143902866 @default.
- W99683634 hasRelatedWork W3146698011 @default.
- W99683634 hasRelatedWork W99683634 @default.
- W99683634 hasRelatedWork W2523873300 @default.
- W99683634 hasVolume "20" @default.
- W99683634 isParatext "false" @default.
- W99683634 isRetracted "false" @default.
- W99683634 magId "99683634" @default.
- W99683634 workType "article" @default.