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- W99686833 abstract "Endothelin-1 (ET), an inflammatory mediator, causes potent contraction of airway smooth muscles leading to oxidative stress (OS) by binding to ETA and ETB receptors. We investigated the interaction between the ETA and ETB receptors in contractions and OS on healthy equine bronchial rings. Rings were prepared from right diaphragmatic lobe. Rings for response studies were set in the tissue chambers containing oxygenated Tyrode's solution at 37oC and 2-gm tension was applied. Concentration-response relationships were determined with graded concentrations of ET-1 on control rings, rings incubated with ETA and ETB antagonists, separately and combined. For OS studies, each ring was incubated for 30 min separately with ET, ET+ETA antagonist, ET+ ETB antagonist and ET+ ETA+ETB antagonists. Total reactive oxygen species (ROS), superoxide production and peroxynitrate were determined using Brucker EMX ESR spectrophotometer. ET caused dose-dependent contraction which was enhanced by ETA blockade and was decreased by ETB blockade. Combined blockade significantly inhibited the response by ET. ET-induced total ROS was decreased in all treatments. Superoxide production was slightly decreased by antagonists individually but increased when combined. Peroxynitrate production was increased by ETA antagonist, but decreased in other treatments. The study suggested that an interaction between ET-receptors exists both in contractile response and OS. Supported by USDA Formula Funds (# LA 1433) and EHSP of LSU-SVM." @default.
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- W99686833 date "2009-04-01" @default.
- W99686833 modified "2023-09-25" @default.
- W99686833 title "Evidence for interaction between endothelin receptors in equine airways" @default.
- W99686833 doi "https://doi.org/10.1096/fasebj.23.1_supplement.931.3" @default.
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