FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W9968723> ?p ?o ?g. }

• W9968723 endingPage "8" @default.
• W9968723 startingPage "183" @default.
• W9968723 abstract "Osteogenesis imperfecta (OI) is a genetically heterogeneous disease leading to bone fragility. OI-VI is an autosomal-recessive form caused by mutations in SERPINF1. There is experimental evidence suggesting that loss of functional SERPINF1 leads to an activation of osteoclasts via the RANK/RANKL pathway. Patients with OI-VI show a poor response to bisphosphonates. We report on four children with OI-VI who had shown continuously elevated urinary bone resorption markers during a previous treatment with bisphosphonates. We treated these children with the RANKL antibody denosumab to reduce bone resorption.Denosumab (1 mg/kg body weight) was injected s.c. every 3 months. There were no severe side effects. Markers of bone resorption decreased to the normal range after each injection. N-terminal Propeptide of collagen 1 was measured in the serum during the first treatment cycle and decreased also. Urinary deoxypyridinoline/creatinine was monitored in a total of seven treatment cycles and indicated that bone resorption reached the pre-treatment level after 6-8 weeks.This was the first use of denosumab in children with OI-VI. Denosumab was well tolerated, and laboratory parameters provided evidence that the treatment reversibly reduced bone resorption. Therefore, denosumab may be a new therapeutic option for patients with OI-VI." @default.
• W9968723 created "2016-06-24" @default.
• W9968723 creator A5013800746 @default.
• W9968723 creator A5060442884 @default.
• W9968723 creator A5075572225 @default.
• W9968723 creator A5079195306 @default.
• W9968723 creator A5083254138 @default.
• W9968723 creator A5089061906 @default.
• W9968723 date "2012-09-01" @default.
• W9968723 modified "2023-09-29" @default.
• W9968723 title "First use of the RANKL antibody denosumab in osteogenesis imperfecta type VI." @default.
• W9968723 cites W1995869907 @default.
• W9968723 cites W2000447888 @default.
• W9968723 cites W2013291868 @default.
• W9968723 cites W2025887657 @default.
• W9968723 cites W2037333809 @default.
• W9968723 cites W2037561180 @default.
• W9968723 cites W2039833863 @default.
• W9968723 cites W2056089881 @default.
• W9968723 cites W2064347506 @default.
• W9968723 cites W2067733866 @default.
• W9968723 cites W2099963180 @default.
• W9968723 cites W2100819070 @default.
• W9968723 cites W2118914286 @default.
• W9968723 cites W2123338348 @default.
• W9968723 cites W2146274306 @default.
• W9968723 cites W2156489046 @default.
• W9968723 cites W2160005424 @default.
• W9968723 cites W2262316124 @default.
• W9968723 cites W2329575366 @default.
• W9968723 cites W2482202957 @default.
• W9968723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22947550" @default.
• W9968723 hasPublicationYear "2012" @default.
• W9968723 type Work @default.
• W9968723 sameAs 9968723 @default.
• W9968723 citedByCount "47" @default.
• W9968723 countsByYear W99687232013 @default.
• W9968723 countsByYear W99687232014 @default.
• W9968723 countsByYear W99687232015 @default.
• W9968723 countsByYear W99687232016 @default.
• W9968723 countsByYear W99687232017 @default.
• W9968723 countsByYear W99687232018 @default.
• W9968723 countsByYear W99687232019 @default.
• W9968723 countsByYear W99687232020 @default.
• W9968723 countsByYear W99687232022 @default.
• W9968723 countsByYear W99687232023 @default.
• W9968723 crossrefType "journal-article" @default.
• W9968723 hasAuthorship W9968723A5013800746 @default.
• W9968723 hasAuthorship W9968723A5060442884 @default.
• W9968723 hasAuthorship W9968723A5075572225 @default.
• W9968723 hasAuthorship W9968723A5079195306 @default.
• W9968723 hasAuthorship W9968723A5083254138 @default.
• W9968723 hasAuthorship W9968723A5089061906 @default.
• W9968723 hasConcept C126322002 @default.
• W9968723 hasConcept C126894567 @default.
• W9968723 hasConcept C131075544 @default.
• W9968723 hasConcept C134018914 @default.
• W9968723 hasConcept C142724271 @default.
• W9968723 hasConcept C146562846 @default.
• W9968723 hasConcept C160160445 @default.
• W9968723 hasConcept C170493617 @default.
• W9968723 hasConcept C181199279 @default.
• W9968723 hasConcept C185592680 @default.
• W9968723 hasConcept C2776286101 @default.
• W9968723 hasConcept C2776541429 @default.
• W9968723 hasConcept C2776886416 @default.
• W9968723 hasConcept C2777308945 @default.
• W9968723 hasConcept C2777668750 @default.
• W9968723 hasConcept C2779428903 @default.
• W9968723 hasConcept C2780787237 @default.
• W9968723 hasConcept C55493867 @default.
• W9968723 hasConcept C673006 @default.
• W9968723 hasConcept C71924100 @default.
• W9968723 hasConcept C88045685 @default.
• W9968723 hasConceptScore W9968723C126322002 @default.
• W9968723 hasConceptScore W9968723C126894567 @default.
• W9968723 hasConceptScore W9968723C131075544 @default.
• W9968723 hasConceptScore W9968723C134018914 @default.
• W9968723 hasConceptScore W9968723C142724271 @default.
• W9968723 hasConceptScore W9968723C146562846 @default.
• W9968723 hasConceptScore W9968723C160160445 @default.
• W9968723 hasConceptScore W9968723C170493617 @default.
• W9968723 hasConceptScore W9968723C181199279 @default.
• W9968723 hasConceptScore W9968723C185592680 @default.
• W9968723 hasConceptScore W9968723C2776286101 @default.
• W9968723 hasConceptScore W9968723C2776541429 @default.
• W9968723 hasConceptScore W9968723C2776886416 @default.
• W9968723 hasConceptScore W9968723C2777308945 @default.
• W9968723 hasConceptScore W9968723C2777668750 @default.
• W9968723 hasConceptScore W9968723C2779428903 @default.
• W9968723 hasConceptScore W9968723C2780787237 @default.
• W9968723 hasConceptScore W9968723C55493867 @default.
• W9968723 hasConceptScore W9968723C673006 @default.
• W9968723 hasConceptScore W9968723C71924100 @default.
• W9968723 hasConceptScore W9968723C88045685 @default.
• W9968723 hasIssue "3" @default.
• W9968723 hasLocation W99687231 @default.
• W9968723 hasOpenAccess W9968723 @default.

• next