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- W996890947 abstract "Publisher Summary This chapter concentrates on the germ cell tumors (GCTs). Germ cells (primordial cells) are cells stored in the male and female reproductive tracts (testis and ovary) that carry the reproductive machinery in both sexes. A unique characteristic of these cells is that they divide by meiosis retaining only half of the cell chromosomes (haploid); thus, when the male sperm cell and female ovum join, the resulting human embryo has normal diploid somatic cell number of chromosomes. Although they have the same function and originate from the same cells, their development, number, maturation, and pathology vary between men and women. Germ cell tumors constitute a remarkably heterogeneous group of neoplasms that can arise from the germ cells in the gonads (testis and ovary) or in extragonadal sites (mainly in the sacrococcygeal region, retroperitoneum, mediastinum, and central nervous system). Despite their common cells of origin, GCTs differ greatly between men and women. In women, ovarian GCTs comprise 15–20% of all ovarian neoplasms, and only 3–5% of these are malignant. Therefore, while GCTs occur more frequently in women than in men, most of these tumors in women are of a benign nature. The pathogenesis, clinical presentation, treatment, and outcome of ovarian germ cell and epithelial cancer are very different. On the other hand, 98% of testicular neoplasms are comprised of testicular GCTs, making it the most common malignancy in American men between the ages of 15 and 34. To understand this significant difference in GCTs between sexes it is necessary to describe the difference in germ cell development." @default.
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- W996890947 date "2010-01-01" @default.
- W996890947 modified "2023-09-26" @default.
- W996890947 title "Difference in Germ Cell Tumors of the Reproductive Tract in Men and Women" @default.
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- W996890947 doi "https://doi.org/10.1016/b978-0-12-374271-1.00043-5" @default.
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