Matches in SemOpenAlex for { <https://semopenalex.org/work/W99690799> ?p ?o ?g. }
- W99690799 endingPage "26" @default.
- W99690799 startingPage "1" @default.
- W99690799 abstract "The 5-HT6 receptor is one of the most recently discovered of the serotonin superfamily of receptors and is a part of the seven-transmembrane G-protein-coupled receptor family that positively couples to Gαs subunits and as such stimulates adenylate cyclase and increases cyclic adenosine monophosphate (cAMP) signaling cascades. This chapter describes the use of ligands through preclinical sampling techniques, such as in vivo microdialysis, discusses the modulatory role of the 5-HT6 receptor on multiple neurotransmitter systems and networks within mammalian brain, and presents the underlying neurobiology of the observed changes along with the potential therapeutic implications and utility of both agonist and antagonist ligands in a range of neurobiological disorders. 5-HT6 receptor ligands can subsequently produce a diverse series of changes in monoaminergic, cholinergic, and excitatory amino acid neurotransmission. The neurochemical data provide supportive evidence and suggest a number of therapeutic avenues that may be pursued for antagonist and, more recently, agonist ligands. This receptor offers much potential as a therapeutic intervention point for a range of central nervous system (CNS)-related disorders and the outcomes of current and future clinical evaluations are awaited with interest and hope." @default.
- W99690799 created "2016-06-24" @default.
- W99690799 creator A5028411455 @default.
- W99690799 date "2011-01-01" @default.
- W99690799 modified "2023-10-03" @default.
- W99690799 title "The Central Role of 5-HT6 Receptors in Modulating Brain Neurochemistry" @default.
- W99690799 cites W180469417 @default.
- W99690799 cites W1894699684 @default.
- W99690799 cites W1964165244 @default.
- W99690799 cites W1964888279 @default.
- W99690799 cites W1967117434 @default.
- W99690799 cites W1973188992 @default.
- W99690799 cites W1977239057 @default.
- W99690799 cites W1981401792 @default.
- W99690799 cites W1981991422 @default.
- W99690799 cites W1984110541 @default.
- W99690799 cites W1985318722 @default.
- W99690799 cites W1985437286 @default.
- W99690799 cites W1986411734 @default.
- W99690799 cites W1988536772 @default.
- W99690799 cites W1995953249 @default.
- W99690799 cites W1997337458 @default.
- W99690799 cites W1998299683 @default.
- W99690799 cites W1998570794 @default.
- W99690799 cites W2003414359 @default.
- W99690799 cites W2003582932 @default.
- W99690799 cites W2003977784 @default.
- W99690799 cites W2004098041 @default.
- W99690799 cites W2008145156 @default.
- W99690799 cites W2011182878 @default.
- W99690799 cites W2011880726 @default.
- W99690799 cites W2011904344 @default.
- W99690799 cites W201431512 @default.
- W99690799 cites W2016430454 @default.
- W99690799 cites W2022769813 @default.
- W99690799 cites W2022809683 @default.
- W99690799 cites W2023235142 @default.
- W99690799 cites W2023706414 @default.
- W99690799 cites W2025196722 @default.
- W99690799 cites W2028287654 @default.
- W99690799 cites W2028306465 @default.
- W99690799 cites W2028541643 @default.
- W99690799 cites W2030360517 @default.
- W99690799 cites W2031164126 @default.
- W99690799 cites W2032011535 @default.
- W99690799 cites W2036843695 @default.
- W99690799 cites W2038187008 @default.
- W99690799 cites W2039294854 @default.
- W99690799 cites W2045796301 @default.
- W99690799 cites W2048045034 @default.
- W99690799 cites W2048159519 @default.
- W99690799 cites W2052719913 @default.
- W99690799 cites W2052923849 @default.
- W99690799 cites W2058984805 @default.
- W99690799 cites W2062174853 @default.
- W99690799 cites W2062495736 @default.
- W99690799 cites W2063206276 @default.
- W99690799 cites W2076144045 @default.
- W99690799 cites W2076240748 @default.
- W99690799 cites W2076488791 @default.
- W99690799 cites W2076977175 @default.
- W99690799 cites W2084216816 @default.
- W99690799 cites W2088133214 @default.
- W99690799 cites W2089571094 @default.
- W99690799 cites W2091627684 @default.
- W99690799 cites W2093359958 @default.
- W99690799 cites W2095460819 @default.
- W99690799 cites W2099424170 @default.
- W99690799 cites W2099635835 @default.
- W99690799 cites W2103714082 @default.
- W99690799 cites W2104041690 @default.
- W99690799 cites W2109645417 @default.
- W99690799 cites W2120481681 @default.
- W99690799 cites W2120641846 @default.
- W99690799 cites W2123262275 @default.
- W99690799 cites W2126508833 @default.
- W99690799 cites W2126699521 @default.
- W99690799 cites W2127948169 @default.
- W99690799 cites W2130119762 @default.
- W99690799 cites W2135134122 @default.
- W99690799 cites W2153200821 @default.
- W99690799 cites W2156305454 @default.
- W99690799 cites W2160999761 @default.
- W99690799 cites W2162933869 @default.
- W99690799 cites W2745524785 @default.
- W99690799 cites W4241804791 @default.
- W99690799 cites W4249009972 @default.
- W99690799 doi "https://doi.org/10.1016/b978-0-12-385902-0.00001-2" @default.
- W99690799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21329782" @default.
- W99690799 hasPublicationYear "2011" @default.
- W99690799 type Work @default.
- W99690799 sameAs 99690799 @default.
- W99690799 citedByCount "32" @default.
- W99690799 countsByYear W996907992013 @default.
- W99690799 countsByYear W996907992014 @default.
- W99690799 countsByYear W996907992015 @default.
- W99690799 countsByYear W996907992016 @default.
- W99690799 countsByYear W996907992017 @default.