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• W99691465 startingPage "95" @default.
• W99691465 abstract "Since its early success in the 1950s, hematopoietic stem cell transplantation (HSCT) has continued to be carried out exponentially worldwide rising to over 7,000 transplants alone across Europe in 2007. HSCT is the major curative therapy for leukemia, lymphoma and other hematological diseases such as aplastic anemia and congenital immunodeficiency diseases such as severe combined immunodeficiency [1, 2]. In recent years it has also been used to downregulate autoimmune diseases with success in juvenile rheumatoid arthritis and systemic lupus erythematosus [3, 4]. Allogeneic HSCT, however, still has a 40–50% risk of morbidity and mortality, largely due to complications that arise post-transplant, such as infection and graft-versus-host disease (GvHD). Matching between recipient and donor at human leukocyte antigen (HLA) loci is imperative to reduce GvHD, and among patients receiving transplants from matched unrelated donors (MUD), mismatches at either HLA Class I or Class II result in increased risk of GvHD, graft failure and overall survival [5]. Over the last 20 years, therefore, in vitro methods of predicting GvHD have been developed. Originally the mixed lymphocyte reaction (MLR) was used to identify responder lymphocytes in HLA-mismatched patient/donor pairs. The results, however, were too insensitive to correlate with GvHD responses post-transplant [6, 7]. Modifications of the MLR, utilizing limiting dilution techniques, diluting responder cells against a standard number of recipient lymphocytes and measuring either cytotoxic T lymphocyte precursor (CTLp) frequencies using tritiated thymidine uptake or helper T lymphocyte precursor (HTLp) responses measuring interleukin-2 (IL-2) production, were used and results assessed against post-transplant GvHD outcome [8–12]. Although CTLp frequencies correlated with both degree of HLA-mismatch and GvHD in the MUD transplant" @default.
• W99691465 created "2016-06-24" @default.
• W99691465 creator A5018712490 @default.
• W99691465 creator A5068477953 @default.
• W99691465 date "2008-10-06" @default.
• W99691465 modified "2023-09-25" @default.
• W99691465 title "Immunogenomics and Proteomics in Hematopoietic Stem Cell Transplantation: Predicting Post-Hematopoietic Stem Cell Transplant Complications" @default.
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