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- W996975945 abstract "This chapter describes the synthesis and chemistry of antifungal agents. A review of the treatment of mycoses by use of antibiotics such as griseofulvin, nystatin, amphotericin B, pimaricin, 5-fluoro-cytosine, trichomycin, cycloheximide, clotrimazole, and miconazole covers the source of the antibiotic, chemistry, in vitro effects, clinical dosages, together with indications and side effects. A new animal model for acute oral candidiasis in rats may provide an additional system for the preclinical evaluation of new antifungal agents. Experimentally induced blastomycosis and histoplasmosis tend to mimic natural infections and are susceptible to amphotericin B therapy. Use of analog-resistant mutants to increase levels of end products, has been directed towards biosynthesis of pyrrolnitrins. β-Alanine has been shown to increase the yield of antifungal antibiotic AYF produced by Streptomyces aureofaciens. UV light and X-ray generate low-producing mutants as well as high producing mutants of Streptomyces nigrifaciens, with reference to antifungal production. Griseofulvin continues to be the main oral therapy for a number of dermatophyte infections and attempts to improve the speed and degree of absorption of griseofulvin following oral administration have continued. Dispersions of griseofulvin in a solid matrix of polyethylene glycol 6000, is demonstrated to lead to higher serum levels in man than those obtained with commercial micronized griseofulvin." @default.
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- W996975945 date "1972-01-01" @default.
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- W996975945 title "Chapter 11. Antifungal Agents" @default.
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- W996975945 doi "https://doi.org/10.1016/s0065-7743(08)60806-4" @default.
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