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- W99705991 abstract "Brain microvessels were isolated from late gestation fetal (55-68 days), newborn (5-9 day old) and adult guinea pigs. Glucose transport was assessed by measuring the initial uptake of ({sup 3}H)-2-deoxy-D-glucose, a glucose analog that is transported and phosphorylated but not further metabolized. At 22C and substrate concentrations of 40 mM, uptakes were linear for 8 minutes. The data reported here were uptakes over the first 2 minutes. 2-deoxy-D-glucose uptake was 3.5 fold higher in newborn microvessels, 99.5{+-}18.4 (SEM) fmols/mg protein/2 minutes, compared to fetal, 27.8{+-}7.9. The number of glucose transporters was estimated using the ({sup 3}H) cytochalasin B which can be displaced by D-glucose (250 mM). Binding at 35 nM cytochalasin B was higher in newborn brain microvessels (8.2{+-}1.6 pmole/mg protein) than in fetal (3.4{+-}1.1) or adult (2.8{+-}0.6) brain microvessels. Initial RNA blot experiments using a cDNA for the brain/erythrocyte (HepG2) glucose transporter show increased expression in newborn microvessels compared to the fetus or the adult. The authors conclude that the brain microvessel glucose transporter is increased in the newborn period." @default.
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- W99705991 date "1990-02-26" @default.
- W99705991 modified "2023-09-27" @default.
- W99705991 title "Developmental expression of the glucose transporter in brain microvessels" @default.
- W99705991 hasPublicationYear "1990" @default.
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