Matches in SemOpenAlex for { <https://semopenalex.org/work/W997069108> ?p ?o ?g. }
- W997069108 endingPage "47" @default.
- W997069108 startingPage "40" @default.
- W997069108 abstract "Abstract Fetal testosterone significantly influences the brain development. It affects number of neurons and conformation of dendritic spines within the sexual dimorphic preoptic area in the hypothalamus. Excessive testosterone levels in utero possibly contribute to the masculinization of the brain. Evidences of these facts are plausible in the anatomic field as well as behavioral effects both in rat models and in humans. Rats exposed to excessive testosterone doses in utero show masculinized brain anatomy and behavior, such as better spatial visualization performance typical for males. In humans, congenital adrenal hyperplasia that causes elevated androgen level possibly results in masculinized behavior observed in these individuals. There are reasons for the theory of the connection existence between testosterone influence on the brain functions and the pathogenesis of neurodevelopmental disorders. In this review, pathogenesis of autism, the most genetic neurodevelopmental disease is discussed. Autism is a disease with broad genetic heterogeneity and polygenic inheritance. Autism associated genes are localized throughout the genome, with the chromosome 7q most frequently involved. One of these genes encodes reelin protein that is crucial for neuronal migration in the developing brain. The connection between androgens, neuronal migration and neurodevelopmental disorder pathophysiology is also discussed." @default.
- W997069108 created "2016-06-24" @default.
- W997069108 creator A5010240139 @default.
- W997069108 creator A5038098778 @default.
- W997069108 date "2008-09-01" @default.
- W997069108 modified "2023-09-25" @default.
- W997069108 title "Androgens Contribute to the Process of Neuronal Development: Implications in Explanation of Autism Pathogenesis" @default.
- W997069108 cites W1503707236 @default.
- W997069108 cites W1789054710 @default.
- W997069108 cites W1966023357 @default.
- W997069108 cites W1966161684 @default.
- W997069108 cites W1970120223 @default.
- W997069108 cites W1971016056 @default.
- W997069108 cites W1972712078 @default.
- W997069108 cites W1978820887 @default.
- W997069108 cites W1979890518 @default.
- W997069108 cites W1980625058 @default.
- W997069108 cites W1982018791 @default.
- W997069108 cites W1986579353 @default.
- W997069108 cites W1992423329 @default.
- W997069108 cites W1992878104 @default.
- W997069108 cites W2005149292 @default.
- W997069108 cites W2006901439 @default.
- W997069108 cites W2011001109 @default.
- W997069108 cites W2012043101 @default.
- W997069108 cites W2014413770 @default.
- W997069108 cites W2014878138 @default.
- W997069108 cites W2016988090 @default.
- W997069108 cites W2030231810 @default.
- W997069108 cites W2032533758 @default.
- W997069108 cites W2035706316 @default.
- W997069108 cites W2037007725 @default.
- W997069108 cites W2042549272 @default.
- W997069108 cites W2044970885 @default.
- W997069108 cites W2048856370 @default.
- W997069108 cites W2054235149 @default.
- W997069108 cites W2078141119 @default.
- W997069108 cites W2078344164 @default.
- W997069108 cites W2080748761 @default.
- W997069108 cites W2083835125 @default.
- W997069108 cites W2091793491 @default.
- W997069108 cites W2102203964 @default.
- W997069108 cites W2111516838 @default.
- W997069108 cites W2126545312 @default.
- W997069108 cites W2131541104 @default.
- W997069108 cites W2135773606 @default.
- W997069108 cites W2136985801 @default.
- W997069108 cites W2139092938 @default.
- W997069108 cites W2142056327 @default.
- W997069108 cites W2142739418 @default.
- W997069108 cites W2143668648 @default.
- W997069108 cites W2144696231 @default.
- W997069108 cites W2152917714 @default.
- W997069108 cites W2166405911 @default.
- W997069108 cites W2170760423 @default.
- W997069108 cites W2171804213 @default.
- W997069108 doi "https://doi.org/10.1007/bf03379917" @default.
- W997069108 hasPublicationYear "2008" @default.
- W997069108 type Work @default.
- W997069108 sameAs 997069108 @default.
- W997069108 citedByCount "4" @default.
- W997069108 countsByYear W9970691082019 @default.
- W997069108 countsByYear W9970691082022 @default.
- W997069108 crossrefType "journal-article" @default.
- W997069108 hasAuthorship W997069108A5010240139 @default.
- W997069108 hasAuthorship W997069108A5038098778 @default.
- W997069108 hasBestOaLocation W9970691081 @default.
- W997069108 hasConcept C104317684 @default.
- W997069108 hasConcept C126322002 @default.
- W997069108 hasConcept C134018914 @default.
- W997069108 hasConcept C138496976 @default.
- W997069108 hasConcept C15744967 @default.
- W997069108 hasConcept C169760540 @default.
- W997069108 hasConcept C170493617 @default.
- W997069108 hasConcept C205778803 @default.
- W997069108 hasConcept C2777911890 @default.
- W997069108 hasConcept C2778063154 @default.
- W997069108 hasConcept C2779279991 @default.
- W997069108 hasConcept C2779388368 @default.
- W997069108 hasConcept C2780942790 @default.
- W997069108 hasConcept C54355233 @default.
- W997069108 hasConcept C63405245 @default.
- W997069108 hasConcept C71315377 @default.
- W997069108 hasConcept C71924100 @default.
- W997069108 hasConcept C86803240 @default.
- W997069108 hasConceptScore W997069108C104317684 @default.
- W997069108 hasConceptScore W997069108C126322002 @default.
- W997069108 hasConceptScore W997069108C134018914 @default.
- W997069108 hasConceptScore W997069108C138496976 @default.
- W997069108 hasConceptScore W997069108C15744967 @default.
- W997069108 hasConceptScore W997069108C169760540 @default.
- W997069108 hasConceptScore W997069108C170493617 @default.
- W997069108 hasConceptScore W997069108C205778803 @default.
- W997069108 hasConceptScore W997069108C2777911890 @default.
- W997069108 hasConceptScore W997069108C2778063154 @default.
- W997069108 hasConceptScore W997069108C2779279991 @default.
- W997069108 hasConceptScore W997069108C2779388368 @default.
- W997069108 hasConceptScore W997069108C2780942790 @default.