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• W997173626 abstract "Latar belakang: Pityriasis rosea merupakan penyakit inflamasi kulit akut bersifat swa-sirna dengan penyebab yang tidak diketahui dengan pasti, patogenesisnya pernah diduga melibatkan reaksi hipersensitivitas selular. Terapi spesifik pityriasis rosea sampai saat ini belum ada penelitian berbasis bukti medis yang masuk kategori I dan II. Fototerapi dengan ultraviolet B (UVB) pernah terbukti dapat menurunkan keparahan penyakit, namun paparan UVB pada kulit dapat mengakibatkan inflamasi akut. Olium olivarum topikal terbukti dapat bekerja sebagai anti-inflamasi pada percobaan binatang. Pengaruh olium oilvarum topikal pasca fototerapi UVB pada keberhasilan terapi pityriasis rosea belum diketahui. Tujuan penelitian: Untuk mengetahui efikasi terapi olium oilvarum topikal pasca fototerapi UVB dibandingkan dengan fototerapi UVB. Hipotesis: Terapi olium oilvarum topikal pasca fototerapi UVB lebih berdaya guna menurunkan rerata pityriasis rosea severity score (PRSS) berbeda bermakna dibandingkan fototerapi UVB. Disain: Rancangan penelitian ini menggunakan uji klinis acak terkendali buta ganda disain paralel. Tempat: Poliklinik Kulit dan Kelamin RS Dr. Sardjito. Subyek Penelitian: Lima puluh tujuh pasien pityriasis rosea diikutkan dalam penelitian. Perlakuan: Unit intervensi pada penelitian ini kulit pasien pityriasis rosea yang akan dibagi menjadi dua regio kanan dan kiri. Lima puluh tujuh kulit pasien (sebelah kanan atau kiri) sebagai kelompok “subyek” akan diterapi dengan olium oilvarum topikal pasca fototerapi UVB. Lima puluh tujuh kulit pasien (sebelah kanan atau kiri) sebagai kelompok “kontrol” akan diterapi dengan fototerapiUVB. Variabel: Keparahan pityriasis rosea diukur dengan PRSS. Rasa gatal, gangguan tidur, dan gangguan kerja diukur dengan visual analog scale. Statistik: Unit analisis pada penelitian ini adalah penurunan rerata PRSS. Perbedaaan penurunan rerata PRSS pada kelompok “subyek” dan kelompok “kontrol” akan dianalisis dengan independent t test repeated measurement.Background: Pityriasis rosea is an acute self-limited inflammatory skin dermatoses of unknown cause, with its patogenesis have been considered as delayed hypersensitivity type involvement. There was no specific treatment modality ranked in Level I or II of evidence based medicine. Ultraviolet B (UVB) phototherapy has been proved to relieve the severity of disease; however it has an acute skin inflammatory effect. Topical olium olivarum has an anti-inflammatory effect in animal study. The efficacy of combination topical olium oilvarum and UVB phototherapy compared with UVB phototherapy in the management of pityriasis rosea has been undefined before. Objective: To assess the efficacy of combination topical olium oilvarum and UVB phototherapy compared with UVB phototherapy. Hypothesis: Combination topical olium oilvarum and UVB phototherapy is more efficacious significant than UVB phototherapy to decrease the mean of PRSS (pityriasis rosea severity score). Design: A randomized-double-blind-controlled-parallel design-clinical trial. Setting: Outpatient at dermatovenerelogy clinic Sardjito hospital. Participants: Fifty six volunteer with pityriasis rosea were enrolled. Intervention: Intervention unit is the skin of patient that will be divided into two region left and right. Fifty six of the half body surface (left or right) defined as “intervention” group will be treated with combination topical olium oilvarum and UVB phototherapy. Fifty six of the others half body surface defined as “control” group (left or right) will be treated UVB phototherapy. Variable: The severity of disease will be measured with pityriasis rosea severity score (PRSS). Subjective symptom will be measured by visual analogue scale. Statistic: Analysis unit is the decreasing of PRSS mean. The differentiation of the decreasing of PRSS mean will be analyzed by independent t test repeated measurement." @default.
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• W997173626 date "2004-01-01" @default.
• W997173626 modified "2023-09-24" @default.
• W997173626 title "Uji klinis efikasi terapi Olium olivarum topikal pasca fototerapi UVB pada Pityriasis Rosea" @default.
• W997173626 hasPublicationYear "2004" @default.
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