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- W99726639 abstract "Publisher Summary This chapter discusses the effect of intestinal microenvironment on mucosal immune response to viruses. The observations summarized in the chapter suggest that the gastrointestinal tract serves as an important interface between ingested elements of the external milieu and the internal environment. Exposure of the gut mucosal surfaces to a variety of infectious and noninfectious agents triggers a complex chain of immunological reactions. A combination of nonspecific and immunologically specific events ultimately determines the outcome of host-pathogen interaction. In most instances of viral or bacterial infection, the appearance of antigen-specific immunoglobulin A (IgA) confers varying degrees of protection against subsequent reinfection challenges. In addition, cell-mediated immune responses evoked at mucosal levels provide major contributions to the mechanism of local protection. The intestine has been shown to be an important portal of entry for many viral infections. Development of natural infection through such mucosal routes in general confers immunity superior to just immunization via nonmucosal routes." @default.
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- W99726639 date "1993-01-01" @default.
- W99726639 modified "2023-09-27" @default.
- W99726639 title "Effect of Intestinal Microenvironment on Mucosal Immune Response to Viruses" @default.
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- W99726639 doi "https://doi.org/10.1016/b978-0-12-732085-4.50033-3" @default.
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