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- W997324891 abstract "Casein kinases are ubiquitous Ca2+- and cyclic nucleotide-independent protein kinases, originally characterized on the basis of their preference for acidic substrates such as casein. Yck1 and Yck2 are a functionally redundant pair of casein kinase I homologues in Saccharomyces cerevisiae. The genes were isolated by virtue of their effects in high dosage. YCK1 was found as a multicopy suppressor of growth defects associated with reduced Snf1 activity, and YCK2 was identified by the protection it provides from the deleterious effects of sudden shifts to high salinity. Increased dosage of either gene has the same effect in either assay. The same pair of genes was independently cloned using degenerate oligonucleotides based on peptide sequence obtained from purified protein. The kinase domains are 94% identical between the two homologues; overall, Yck1 and Yck2 are 77% identical. As with other members of the CKI family, the kinase domain sequence differs from those of other kinases by the absence of the conserved APE motif in subdomain VIII and the conserved Arg residue in subdomain XI. The C-terminal portions of Yck1 and Yck2 contain regions that are 47% and 43% glutamine residues, respectively." @default.
- W997324891 created "2016-06-24" @default.
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- W997324891 date "1995-01-01" @default.
- W997324891 modified "2023-09-23" @default.
- W997324891 title "Yck1/2" @default.
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- W997324891 doi "https://doi.org/10.1016/b978-012324719-3/50117-5" @default.
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