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- W997333483 abstract "Clinical studies have demonstrated that rosiglitazone can improve vascular function in patients with diabetes mellitus. It remains unclear whether this effect depends on a direct improvement in endothelial function or whether it is mediated by the drug's effect on glycemic control. Yet, rosiglitazone has been linked to serious cardiovascular events. A number of studies recently investigated whether rosiglitazone affects endothelial function in healthy volunteers and patients with cardiovascular disease. Controversial observations have been reported; the observation that rosiglitazone might in certain cases impair endothelial function may suggest a mechanistic explanation for the observation of increased cardiovascular events in patients treated with rosiglitazone who have underlying cardiovascular disease. These studies are summarized and discussed in the present paper." @default.
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- W997333483 date "2010-01-01" @default.
- W997333483 modified "2023-09-25" @default.
- W997333483 title "The impact of rosiglitazone on nitric oxide bioavailability and endothelial function" @default.
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- W997333483 doi "https://doi.org/10.3233/ch-2010-1315" @default.
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