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- W997411568 abstract "目的观察糖尿病易感患者酗酒时血清肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)、白介素-6(IL-6)、谷氨酸脱羧酶抗体(GADA)水平的变化。方法选择一组(n=62)有糖尿病家族史的酗酒者体重指数和血脂正常为A组(n=28)、有糖尿病家族史的酗酒者体重指数和血脂升高为B组(n=34)、2型糖尿病患者为C组(n=23)、正常对照组为D组(n=21),分别测定血清TNF—α、IL—1、IL-6、GADA毒平的变化,有糖尿病家族史的酗酒者停酒3个月后再次检测血清TNF—α、IL-1、IL-6、GADA水平的变化。组间均数比较采用t检验。结果A组患者酗酒时血清TNF-α、IL-1、IL-6、GADA水平高于D组(P〈0.05),B组血清TNF—α、IL-1、IL-6、GADA水平高于D组(P〈0.05),C组患者血清TNF-α、IL-1、IL-6、GADA水平明显高于D组(P〈0.01);糖尿病易感患者酗酒者在停酒3月后再次检测血清TNF—α、IL-1、IL-6、GADA水平下降(P〈0.05)。结论糖尿病易感患者酗酒时乙醇诱发和/或加重胰岛素抵抗、使岛β细胞的损伤,由此导致糖代谢紊乱的发生和发展。" @default.
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- W997411568 date "2008-01-01" @default.
- W997411568 modified "2023-09-28" @default.
- W997411568 title "乙醇对糖尿病易感患者血清肿瘤坏死因子-α、白介素-1、白介素-6、谷氨酸脱羧酶抗体水平的影响" @default.
- W997411568 hasPublicationYear "2008" @default.
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