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- W99758426 abstract "A common approach for investigating evolutionary relationships between genes and organisms is to compare extant DNA or protein sequences and infer an evolutionary tree. This methodology is known as molecular phylogenetics and may be the most informative means for exploring phage evolution, since there are few morphological features that can be used to differentiate between these tiny biological entities. In addition, phage genomes can be mosaic, meaning different genes or genomic regions can exhibit conflicting evolutionary histories due to lateral gene transfer or homologous recombination between different phage genomes. Molecular phylogenetics can be used to identify and study such genome mosaicism. This chapter provides a general introduction to the theory and methodology used to reconstruct phylogenetic relationships from molecular data. Also included is a discussion on how the evolutionary history of different genes within the same set of genomes can be compared, using a collection of T4-type phage genomes as an example. A compilation of programs and packages that are available for conducting phylogenetic analyses is supplied as an accompanying appendix." @default.
- W99758426 created "2016-06-24" @default.
- W99758426 creator A5070176943 @default.
- W99758426 creator A5073836488 @default.
- W99758426 date "2009-01-01" @default.
- W99758426 modified "2023-09-25" @default.
- W99758426 title "Molecular Phylogenetics: Testing Evolutionary Hypotheses" @default.
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- W99758426 doi "https://doi.org/10.1007/978-1-60327-565-1_9" @default.
- W99758426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19082555" @default.
- W99758426 hasPublicationYear "2009" @default.
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