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- W997644502 abstract "The effect of ethinyl estradiol medroxyprogesterone acetate and 3 oral contraceptive preparations (Enovid E Enovid Provest) on experimen tal allergic encephalomyelitis (EAE) was studies. .005 mg/day ethinyl estradiol prevented the development of EAE in rats immunized with .2 mg of 10% rat cord in Freunds adjuvant. 8 of 10 controls showed histologic EAE at sacrifice 3 weeks postimmunization; in 6 it was severe. 2 of 9 ethinyl estradiol-treated rats showed histologic EAE and in only 1 was it severe (p greater than .01). Clinical disease was inhibited and the treated gained while the controls lost weight. 1 mg medroxyprogesterone acetate did not inhibit EAE in rats immunized with 10% rat cord. 14 of 17 treated showed histologic lesions (11 were severe) which was comparable with the untreated controls. 21 of 31 controls showed clinical disease whereas all 17 treated rats showed clinical disease indicating medroxyprogesterone acetate exacerbated EAE. The 3 combination OCs all inhibited EAE at 3 weeks in rats immunized with 10% rat cord. When kept for 6 weeks Enovid E and Enovid groups remained disease-free whereas 8 of 11 treated with Provest showed disease. Since EAE mimics multiple sclerosis (MS) clinically and pathologically the question of whether women with MS should be given OCs arises frequently. It was suggested that those OCs with the highest estrogen-to-progestin ratio be favored in patients with MS." @default.
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- W997644502 date "1969-01-01" @default.
- W997644502 modified "2023-09-23" @default.
- W997644502 title "Effects of estrogen, progestin and combined estrogen-progestin oral contraceptive preparations on experimental allergic encephalomyelitis." @default.
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