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- W998360520 abstract "Publisher Summary This chapter focuses on advances made in research on atherosclerosis, which is defined by the WHO “as a variable combination of changes of the intima of arteries consisting of the focal accumulation of lipids, complex carbohydrates, blood and blood products, fibrous tissue and calcium deposits and associated with medial changes.” Life style is apparently an important facet in the development of atherosclerosis. Although the disease is universal, its greatest prevalence is generally found among the more technologically developed or affluent countries. This has been underscored in studies with groups of people migrating from areas with low atherosclerotic incidence to regions with high incidence of the disease. Environmental or risk factors have been investigated as possible contributors to disease development. Diet, lack of exercise, stress, cigarette smoking, hypertension, and serum lipid levels have each been correlated with atherosclerosis. The chapter discusses the current concept of atherosclerosis formation, which postulates that arterial injury occurs first, followed by a sequence of events culminating in plaque deposits. The prevailing therapeutic approach to atherosclerosis, which focuses on the treatment of hyperlipidemia, hypertension, obesity, diabetes, and other associated pathologies have been discussed." @default.
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- W998360520 date "1971-01-01" @default.
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- W998360520 title "Chapter 16. Atherosclerosis" @default.
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- W998360520 doi "https://doi.org/10.1016/s0065-7743(08)60971-9" @default.
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