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- W998409872 abstract "目的：探讨吡格列酮对THP-1源性巨噬细胞ATP结合盒转运蛋白A1（ABCA1）、ATP结合盒转运蛋白G1（ABCG1）及B族Ⅰ型清道夫受体（SR-BⅠ）表达的影响及可能作用机制。方法：Real time PCR及Western-blot检测不同浓度吡格列酮（1,10,20,30μmol/L）作用24h,THP-1源性巨噬细胞ABCA1,ABCG1及SR-BⅠmRNA和蛋白的表达。使用过氧化物酶体增殖物激活型受体γ（PPARγ）特异性拮抗剂GW9662（2μmol/L）阻断吡格列酮（10μmol/L）,24h后检测THP-1源性巨噬细胞ABCA1,ABCG1及SR-BⅠmRNA和蛋白的表达。结果：吡格列酮可浓度依赖性增高24hTHP-1源性巨噬细胞ABCA1,ABCG1及SR-BⅠmRNA和蛋白的表达,GW9662可显著抑制吡格列酮诱导的THP-1源性巨噬细胞ABCA1,ABCG1及SR-BⅠmRNA和蛋白表达的增高（P〈0.05）。结论：吡格列酮激动PPARγ上调THP-1源性巨噬细胞胆固醇流出调节蛋白ABCA1,ABCG1及SR-BⅠ基因的表达。" @default.
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- W998409872 date "2012-01-01" @default.
- W998409872 modified "2023-09-28" @default.
- W998409872 title "吡格列酮对THP-1源性巨噬细胞胆固醇流出调节蛋白ABCA1,ABCG1及SR-BI表达的影响" @default.
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