Matches in SemOpenAlex for { <https://semopenalex.org/work/W998718119> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W998718119 endingPage "210" @default.
- W998718119 startingPage "190" @default.
- W998718119 abstract "This chapter provides an overview of dominant metastasis-associated genes. The chapter begins with a discussion on mta1 gene expression in mammary carcinoma and adenocarcinoma cell lines. The mta1 is expressed at a low level in several organs, with the exception of testes where its expression is very high. The gene shows markedly greater expression in metastatic tumors compared with nonmetastatic ones. A fourfold higher expression is found in the highly metastatic MTLn3 cell line than in the nonmetastatic cell line, MTC4. The levels of transcripts of the human homolog of mta1 have been examined in human tumors, and a marked increase in the transcription of the gene is noted in association with an increase in the invasive and metastatic abilities of MCF7 and MDA breast cancer cell lines. This chapter explains in detail concepts related to the role of murine 18A2/mts1 homologs and other S-100 proteins in cancer progression. It also describes structure and function of S-100 family proteins, as well as the structure and organization of S-100 family genes. The chapter elaborates the expression of S-l00 proteins in cell proliferation, differentiation, and neoplasia. The chapter concludes with a discussion on molecular mechanisms of regulation of metastasis by 18A2/mts1 gene and its homologs." @default.
- W998718119 created "2016-06-24" @default.
- W998718119 creator A5042571618 @default.
- W998718119 creator A5087553827 @default.
- W998718119 date "1997-01-01" @default.
- W998718119 modified "2023-10-16" @default.
- W998718119 title "Dominant metastasis-associated genes" @default.
- W998718119 doi "https://doi.org/10.1016/b978-012639875-5/50015-7" @default.
- W998718119 hasPublicationYear "1997" @default.
- W998718119 type Work @default.
- W998718119 sameAs 998718119 @default.
- W998718119 citedByCount "0" @default.
- W998718119 crossrefType "book-chapter" @default.
- W998718119 hasAuthorship W998718119A5042571618 @default.
- W998718119 hasAuthorship W998718119A5087553827 @default.
- W998718119 hasConcept C104317684 @default.
- W998718119 hasConcept C121608353 @default.
- W998718119 hasConcept C1491633281 @default.
- W998718119 hasConcept C150194340 @default.
- W998718119 hasConcept C2779013556 @default.
- W998718119 hasConcept C2909960190 @default.
- W998718119 hasConcept C502942594 @default.
- W998718119 hasConcept C54355233 @default.
- W998718119 hasConcept C5911399 @default.
- W998718119 hasConcept C81885089 @default.
- W998718119 hasConcept C86339819 @default.
- W998718119 hasConcept C86803240 @default.
- W998718119 hasConceptScore W998718119C104317684 @default.
- W998718119 hasConceptScore W998718119C121608353 @default.
- W998718119 hasConceptScore W998718119C1491633281 @default.
- W998718119 hasConceptScore W998718119C150194340 @default.
- W998718119 hasConceptScore W998718119C2779013556 @default.
- W998718119 hasConceptScore W998718119C2909960190 @default.
- W998718119 hasConceptScore W998718119C502942594 @default.
- W998718119 hasConceptScore W998718119C54355233 @default.
- W998718119 hasConceptScore W998718119C5911399 @default.
- W998718119 hasConceptScore W998718119C81885089 @default.
- W998718119 hasConceptScore W998718119C86339819 @default.
- W998718119 hasConceptScore W998718119C86803240 @default.
- W998718119 hasLocation W9987181191 @default.
- W998718119 hasOpenAccess W998718119 @default.
- W998718119 hasPrimaryLocation W9987181191 @default.
- W998718119 hasRelatedWork W1565897669 @default.
- W998718119 hasRelatedWork W2007559212 @default.
- W998718119 hasRelatedWork W2009966535 @default.
- W998718119 hasRelatedWork W2013108791 @default.
- W998718119 hasRelatedWork W2122540340 @default.
- W998718119 hasRelatedWork W2153170533 @default.
- W998718119 hasRelatedWork W2292529151 @default.
- W998718119 hasRelatedWork W2363344444 @default.
- W998718119 hasRelatedWork W2364773096 @default.
- W998718119 hasRelatedWork W2907705195 @default.
- W998718119 isParatext "false" @default.
- W998718119 isRetracted "false" @default.
- W998718119 magId "998718119" @default.
- W998718119 workType "book-chapter" @default.