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- W998721540 abstract "Objective:To study the protective effect of Naomaian capsule on focal cerebral ischemia in rat neurons. Methods: Rat models of focal cerebral ischemia were established by thread ligation in middle cerebral artery occlusions(MCAO). After 24 hours, the brains were removed to observe the morphological changes of rat cerebral cortical neurons under optical microscope through HE staining, detect the content of MDA,LD and the activity of SOD,LDH,Na+-K+-ATP enzyme in ischemic cerebral brain by spectrophotometry. Results: Compared with control, ischemia models group have obviously neurological defi cits. Cerebral cortex has signifi cant ischemic morphologic changes, such as neuronal edema. The content of MDA,LD was much higher, that of SOD、LDH and Na+-K+-ATP enzyme was much lower,in ischemia cerebra(P0.01). Naomaian capsule group can be improved neurological defi cits of MCAO rats and reduce neuronal edema. The concentration of MDA,LD were lower, whereas that of SOD,LDH and Na+-K+-ATP enzyme was much higher in Naomaian capsule group(P0.05,P0.01). Conclusion: Naomaian capsule had the effect of lightening the injury degree of brain tissues, inhibiting the production of free radical and decreasing lipid peroxidation. It alleviated cerebral injury and had an obvious protective effect on focal cerebral ischemia in rats, to a certain extent, inhibited the production and the effect of the toxic reaction." @default.
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- W998721540 date "2009-01-01" @default.
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- W998721540 title "Protective effect of Naomaian capsule on oxidative damage after acute cerebral infarction in rats." @default.
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