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- W998822684 abstract "Little has been published on treatment of precocious puberty in girls with Williams-Beuren syndrome (WBS), a condition occurring frequently in this group. We analyzed our own data on growth/age at menarche of now adult female patients with WBS being diagnosed with central precocious puberty or early puberty. Data of patients treated with gonadotropin-releasing hormone (GnRH) analog (n=13) were compared with those not treated (control group, n=11).Longitudinal data on the somatic development of 24 now adult female patients were analyzed.Medium final height was 157.2±6.5 cm compared to 151.4±5.6 cm in the control group. No significant difference could be found in the discrepancy of genetic target height and final height. Prepubertally girls were normal weight in both groups; in adulthood the majority of patients were overweight/obese. Menarche commenced 11 months after cessation of therapy.As already known from other studies, hormonal suppression via GnRH analog was well tolerated." @default.
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- W998822684 date "2015-01-01" @default.
- W998822684 modified "2023-09-25" @default.
- W998822684 title "Treatment of central precocious puberty and early puberty with GnRH analog in girls with Williams-Beuren syndrome" @default.
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- W998822684 doi "https://doi.org/10.1515/jpem-2014-0393" @default.
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