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- W99892844 abstract "Pseudomonas aeruginosa is a ubiquitous Gram-negative bacterium that has adapted to grow in diverse environments, from soil and water reservoirs to the mammalian lung. It is an opportunistic pathogen that utilizes surface and secreted virulence factors, including a potent exotoxin and four type III secreted cytotoxins. The structural, molecular, and functional properties of these toxins have been discussed in this chapter. P. aeruginosa produces three ADP-ribosyltransferases - ETA, ExoS, and ExoT. Both ETA and ExoS contribute to pathogenesis, since strains of P. aeruginosa that are deleted for the genes encoding these proteins are less toxic than parental strains. The role of Psuedomonas cytotoxins in pathogenesis and multiple catalytic activities of ExoS and ExoT,analogous to the type III cytotoxins of Yersinia and Salmonella have been discussed. Since the initial discoveries of ETA and exoenzyme S, progress has been made in characterizing cytotoxins of P. aeruginosa. Their analysis has led to insights into not only toxin biology and virulence mechanisms by pathogenic bacteria, but also the physiology of the mammalian cell. Understanding the function of P. aeruginosa cytotoxins may also lead to therapies to control the pathogenesis of this unique and versatile microorganism. Advances in understanding the action of ETA have also led to the development of therapies to cure specific cancers through immunotherapy, while characterization of the type III secretion system may lead to novel strategies for early detection, and therapies to control P. aeruginosa infections." @default.
- W99892844 created "2016-06-24" @default.
- W99892844 creator A5006264387 @default.
- W99892844 creator A5052920879 @default.
- W99892844 creator A5076200634 @default.
- W99892844 date "2006-01-01" @default.
- W99892844 modified "2023-09-26" @default.
- W99892844 title "Pseudomonas aeruginosa toxins" @default.
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