Matches in SemOpenAlex for { <https://semopenalex.org/work/W99970020> ?p ?o ?g. }
- W99970020 endingPage "126" @default.
- W99970020 startingPage "115" @default.
- W99970020 abstract "Histone H1 preferentially and cooperatively binds scaffold-associated regions (SARs) in vitro via specific interactions with the numerous short A + T-rich tracts (A-tracts) contained in these sequences. Selective titration of A-tracts by the oligopeptide distamycin abolishes this interaction and results in a redistribution of H1. Similarly, treatment of intact cells and isolated nuclei with distamycin specifically enhances cleavage of internucleosomal linkers of SARs by topoisomerase II and restriction enzymes. The increased accessibility of these linkers is thought to result from the unfolding (or opening) of the chromatin fiber and to be due to a reduced occupancy by histone H1. Chromatin extraction and H1 assembly experiments support this view. We discuss a model whereby open, H1-depleted chromatin regions may be generated by titration of A-tracts by putative distamycin analogues; this local opening may spread to adjacent regions assuming highly cooperative H1-H1 interactions in chromatin." @default.
- W99970020 created "2016-06-24" @default.
- W99970020 creator A5008376147 @default.
- W99970020 creator A5027184649 @default.
- W99970020 creator A5030122660 @default.
- W99970020 creator A5082952507 @default.
- W99970020 date "1993-01-01" @default.
- W99970020 modified "2023-09-27" @default.
- W99970020 title "A model for chromatin opening: stimulation of topoisomerase II and restriction enzyme cleavage of chromatin by distamycin." @default.
- W99970020 cites W130386237 @default.
- W99970020 cites W1487114646 @default.
- W99970020 cites W1493549734 @default.
- W99970020 cites W1545156714 @default.
- W99970020 cites W1548068969 @default.
- W99970020 cites W1606632025 @default.
- W99970020 cites W1898174157 @default.
- W99970020 cites W1927950101 @default.
- W99970020 cites W1963658914 @default.
- W99970020 cites W1964971008 @default.
- W99970020 cites W1965987734 @default.
- W99970020 cites W1966532055 @default.
- W99970020 cites W1973105664 @default.
- W99970020 cites W1974115528 @default.
- W99970020 cites W1976121220 @default.
- W99970020 cites W1979371836 @default.
- W99970020 cites W1984221059 @default.
- W99970020 cites W1988664061 @default.
- W99970020 cites W1990343225 @default.
- W99970020 cites W2004215286 @default.
- W99970020 cites W2006569526 @default.
- W99970020 cites W2007156888 @default.
- W99970020 cites W2019441376 @default.
- W99970020 cites W2024985983 @default.
- W99970020 cites W2026115878 @default.
- W99970020 cites W2027041878 @default.
- W99970020 cites W2027305883 @default.
- W99970020 cites W2033241321 @default.
- W99970020 cites W2034796909 @default.
- W99970020 cites W2039313637 @default.
- W99970020 cites W2041517407 @default.
- W99970020 cites W2042491847 @default.
- W99970020 cites W2043734426 @default.
- W99970020 cites W2064377347 @default.
- W99970020 cites W2066341116 @default.
- W99970020 cites W2068779520 @default.
- W99970020 cites W2073281700 @default.
- W99970020 cites W2076358517 @default.
- W99970020 cites W2076614684 @default.
- W99970020 cites W2079314213 @default.
- W99970020 cites W2085064863 @default.
- W99970020 cites W2085742599 @default.
- W99970020 cites W2095565682 @default.
- W99970020 cites W2099114692 @default.
- W99970020 cites W2099590173 @default.
- W99970020 cites W2101383627 @default.
- W99970020 cites W2105450454 @default.
- W99970020 cites W2159348779 @default.
- W99970020 cites W2165090578 @default.
- W99970020 cites W2177510297 @default.
- W99970020 cites W2194296495 @default.
- W99970020 cites W2217532849 @default.
- W99970020 cites W2275131211 @default.
- W99970020 cites W2306710262 @default.
- W99970020 cites W3164715 @default.
- W99970020 doi "https://doi.org/10.1002/j.1460-2075.1993.tb05637.x" @default.
- W99970020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/413181" @default.
- W99970020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8381347" @default.
- W99970020 hasPublicationYear "1993" @default.
- W99970020 type Work @default.
- W99970020 sameAs 99970020 @default.
- W99970020 citedByCount "112" @default.
- W99970020 countsByYear W999700202013 @default.
- W99970020 countsByYear W999700202015 @default.
- W99970020 countsByYear W999700202018 @default.
- W99970020 countsByYear W999700202019 @default.
- W99970020 countsByYear W999700202020 @default.
- W99970020 countsByYear W999700202022 @default.
- W99970020 crossrefType "journal-article" @default.
- W99970020 hasAuthorship W99970020A5008376147 @default.
- W99970020 hasAuthorship W99970020A5027184649 @default.
- W99970020 hasAuthorship W99970020A5030122660 @default.
- W99970020 hasAuthorship W99970020A5082952507 @default.
- W99970020 hasBestOaLocation W999700202 @default.
- W99970020 hasConcept C101152365 @default.
- W99970020 hasConcept C12554922 @default.
- W99970020 hasConcept C13935069 @default.
- W99970020 hasConcept C147897179 @default.
- W99970020 hasConcept C151730666 @default.
- W99970020 hasConcept C153911025 @default.
- W99970020 hasConcept C167227067 @default.
- W99970020 hasConcept C175156509 @default.
- W99970020 hasConcept C2779281246 @default.
- W99970020 hasConcept C43369102 @default.
- W99970020 hasConcept C552990157 @default.
- W99970020 hasConcept C55493867 @default.
- W99970020 hasConcept C64927066 @default.
- W99970020 hasConcept C67258246 @default.
- W99970020 hasConcept C83640560 @default.