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- W999725764 abstract "This chapter overviews the mechanisms underlying the stability and especially the variability of the picornavirus phenotype and genotype. It also talks about the principles of genetic analysis of viral functions and of manipulations with the viral genome. The pathogenic potential of picornaviruses may vary in two respects: (i) viral variants may be more or less virulent, in the sense that different doses of a virus are required to inflict similar clinical signs (at the extreme, even the highest possible dose may fail to produce any signs); and (ii) the variants may cause different clinical patterns. The picornavirus RNA polymerase, like analogous enzymes of other RNA viruses, lacks the ability to remove the erroneously incorporated nucleotide (the proofreading activity), characteristic of many DNA polymerases. Viral RNA rearrangements of any kind (recombination, deletions, insertions) may contribute to genome plasticity and evolution. There are two general approaches to linking specific phenotypic traits to specific genes or their parts: (i) identification of mutations associated with a distinct phenotype, and (ii) observation of phenotypic effects of engineered mutations in specific genes. The current understanding of the mechanisms of picornavirus genome variability and stability is rather superficial and limited." @default.
- W999725764 created "2016-06-24" @default.
- W999725764 creator A5051395220 @default.
- W999725764 date "2014-04-23" @default.
- W999725764 modified "2023-09-26" @default.
- W999725764 title "Picornavirus Genetics: an Overview" @default.
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