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- W999726509 abstract "Publisher Summary This chapter discusses the three representative new approaches to anti-tumor therapy: the circumvention of multidrug resistance, the antagonism of mitogenic growth factors, and finally the inhibition of oncogenic tyrosine kinases. Multidrug resistance (MDR) is characterized by cross-resistance to a group of structurally and mechanistically distinct antitumor agents. MDR can be induced by the expression of human mdr1 cDNA and also by gene transfection. Expression of the mdr1 gene occurs in normal human tissues, such as colon, lung, liver, and kidney, that are frequently exposed to xenobiotics. Thus, inhibition or reversal of the MDR phenotype appears as a promising clinical target for the improvement of current antitumor therapy. In addition to calcium antagonists, a diverse range of structurally and pharmacologically distinct drugs have been shown to reverse MDR. Growth factor involvement in the maintenance of the transformed phenotype is likely to be heterogeneous at the tumor level. The protein tyrosine kinases, that appear to play important roles in the transduction of signals initiating cellular replication and transformation, represent one type of an ever-increasing family of regulatory protein kinases. Protein tyrosine kinases have now been associated with several human cancers. The plethora of protein kinases makes the development of an inhibitor specific for a particular target a formidable task. Selective inhibition of target protein kinases is possible and can result in selective growth inhibition. As specific pharmacologic agents emerge from these areas, their value in antitumor therapies can only be judged in the human clinical trials." @default.
- W999726509 created "2016-06-24" @default.
- W999726509 creator A5033310382 @default.
- W999726509 creator A5082046729 @default.
- W999726509 date "1989-01-01" @default.
- W999726509 modified "2023-09-27" @default.
- W999726509 title "Chapter 13. New Approaches to Antitumor Therapy" @default.
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- W999726509 doi "https://doi.org/10.1016/s0065-7743(08)60535-7" @default.
- W999726509 hasPublicationYear "1989" @default.
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