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- W999738953 abstract "Publisher Summary Local hemodynamic forces actively regulate vascular smooth muscle tone through the phenomenon of flow-dependent dilation, which is principally mediated via nitric oxide (NO) released by the endothelium. This dynamic response contributes to the hydraulic efficiency of the circulation and optimizes perfusion by interacting with myogenic and metabolic control mechanisms. The ability of the endothelial cell to sense shear stress involves an array of signaling pathways and cellular components, including G proteins, caveolae, integrins, and the cytoskeleton, which may all participate in the mechanotransduction mechanisms that lead to the activation of the endothelial NO synthase (eNOS). On a long-term basis, regulation of eNOS by shear forces is thought to contribute to the ability of the vessel wall to remodel and thereby, normalize shear stress following sustained changes in flow. Furthermore, moment-to-moment release of NO and expression of eNOS itself are differentially regulated by steady, pulsatile, and turbulent shear forces. This sensitivity to different flow patterns may explain why certain sites in the circulation are predisposed to the development of disease." @default.
- W999738953 created "2016-06-24" @default.
- W999738953 creator A5070039873 @default.
- W999738953 date "2000-01-01" @default.
- W999738953 modified "2023-10-16" @default.
- W999738953 title "Role of Nitric Oxide in the Regulation of Blood Flow" @default.
- W999738953 cites W105796842 @default.
- W999738953 cites W110224763 @default.
- W999738953 cites W1519102962 @default.
- W999738953 cites W1553826095 @default.
- W999738953 cites W1604362023 @default.
- W999738953 cites W1607892649 @default.
- W999738953 cites W1678757150 @default.
- W999738953 cites W1678800844 @default.
- W999738953 cites W1832498930 @default.
- W999738953 cites W1841050729 @default.
- W999738953 cites W1859822101 @default.
- W999738953 cites W1891216974 @default.
- W999738953 cites W1924909341 @default.
- W999738953 cites W1936770188 @default.
- W999738953 cites W1963493915 @default.
- W999738953 cites W1965155597 @default.
- W999738953 cites W1966255333 @default.
- W999738953 cites W1966358430 @default.
- W999738953 cites W1967091709 @default.
- W999738953 cites W1968402657 @default.
- W999738953 cites W1968553256 @default.
- W999738953 cites W1969923024 @default.
- W999738953 cites W1970522066 @default.
- W999738953 cites W1971453023 @default.
- W999738953 cites W1972789975 @default.
- W999738953 cites W1974332277 @default.
- W999738953 cites W1983069397 @default.
- W999738953 cites W1984241186 @default.
- W999738953 cites W1985093096 @default.
- W999738953 cites W1986733870 @default.
- W999738953 cites W1987262023 @default.
- W999738953 cites W1987876788 @default.
- W999738953 cites W1988957088 @default.
- W999738953 cites W1989012631 @default.
- W999738953 cites W1990992912 @default.
- W999738953 cites W1992914996 @default.
- W999738953 cites W1993013099 @default.
- W999738953 cites W1993533077 @default.
- W999738953 cites W1994802613 @default.
- W999738953 cites W1994931711 @default.
- W999738953 cites W1996728375 @default.
- W999738953 cites W1998603602 @default.
- W999738953 cites W1999160425 @default.
- W999738953 cites W1999312192 @default.
- W999738953 cites W2001152066 @default.
- W999738953 cites W2003615182 @default.
- W999738953 cites W2004205130 @default.
- W999738953 cites W2004472687 @default.
- W999738953 cites W2006405826 @default.
- W999738953 cites W2009551269 @default.
- W999738953 cites W2009825870 @default.
- W999738953 cites W2010704943 @default.
- W999738953 cites W2011138637 @default.
- W999738953 cites W2011299866 @default.
- W999738953 cites W2011801773 @default.
- W999738953 cites W2012152425 @default.
- W999738953 cites W2013275221 @default.
- W999738953 cites W2018251380 @default.
- W999738953 cites W2020310216 @default.
- W999738953 cites W2021992981 @default.
- W999738953 cites W2024033655 @default.
- W999738953 cites W2024450698 @default.
- W999738953 cites W2024556558 @default.
- W999738953 cites W2025393734 @default.
- W999738953 cites W2026729475 @default.
- W999738953 cites W2030036148 @default.
- W999738953 cites W2030071437 @default.
- W999738953 cites W2030537932 @default.
- W999738953 cites W2031216994 @default.
- W999738953 cites W2031995017 @default.
- W999738953 cites W2035508242 @default.
- W999738953 cites W2037507338 @default.
- W999738953 cites W2037867131 @default.
- W999738953 cites W2038307719 @default.
- W999738953 cites W2038802014 @default.
- W999738953 cites W2039625611 @default.
- W999738953 cites W2041075406 @default.
- W999738953 cites W2041854444 @default.
- W999738953 cites W2042217302 @default.
- W999738953 cites W2044521785 @default.
- W999738953 cites W2044697794 @default.
- W999738953 cites W2045406711 @default.
- W999738953 cites W2045476191 @default.
- W999738953 cites W2046265521 @default.
- W999738953 cites W2046278011 @default.
- W999738953 cites W2047471761 @default.
- W999738953 cites W2047715774 @default.
- W999738953 cites W2049215266 @default.
- W999738953 cites W2051638098 @default.
- W999738953 cites W2052364512 @default.
- W999738953 cites W2053066981 @default.
- W999738953 cites W2055054130 @default.