Matches in Ubergraph for { <http://purl.obolibrary.org/obo/MAXO_0000743> ?p ?o ?g. }
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- MAXO_0000743 COB_0000081 BFO_0000001 @default.
- MAXO_0000743 COB_0000081 BFO_0000002 @default.
- MAXO_0000743 COB_0000081 BFO_0000017 @default.
- MAXO_0000743 COB_0000081 BFO_0000020 @default.
- MAXO_0000743 COB_0000081 COB_0000033 @default.
- MAXO_0000743 COB_0000081 COB_0000113 @default.
- MAXO_0000743 COB_0000081 COB_0000120 @default.
- MAXO_0000743 COB_0000081 COB_0000502 @default.
- MAXO_0000743 COB_0000081 OBI_0000260 @default.
- MAXO_0000743 COB_0000081 PATO_0000001 @default.
- MAXO_0000743 COB_0000087 BFO_0000001 @default.
- MAXO_0000743 COB_0000087 BFO_0000002 @default.
- MAXO_0000743 COB_0000087 BFO_0000017 @default.
- MAXO_0000743 COB_0000087 BFO_0000020 @default.
- MAXO_0000743 COB_0000087 BFO_0000023 @default.
- MAXO_0000743 COB_0000087 COB_0000033 @default.
- MAXO_0000743 COB_0000087 COB_0000114 @default.
- MAXO_0000743 COB_0000087 COB_0000123 @default.
- MAXO_0000743 COB_0000087 COB_0000502 @default.
- MAXO_0000743 COB_0000087 PATO_0000001 @default.
- MAXO_0000743 COB_0000087 SEPIO_0000048 @default.
- MAXO_0000743 IAO_0000115 "Treatment with sulfonamide urea derivatives with antihyperglycemic activity." @default.
- MAXO_0000743 MAXO_0000864 BFO_0000001 @default.
- MAXO_0000743 MAXO_0000864 BFO_0000002 @default.
- MAXO_0000743 MAXO_0000864 BFO_0000004 @default.
- MAXO_0000743 MAXO_0000864 BFO_0000040 @default.
- MAXO_0000743 MAXO_0000864 CHEBI_24431 @default.
- MAXO_0000743 MAXO_0000864 COB_0000006 @default.
- MAXO_0000743 date "2020-11-18T16:22:03.000Z" @default.
- MAXO_0000743 creator 0000-0001-7941-2961 @default.
- MAXO_0000743 normalizedInformationContent "100" @default.
- MAXO_0000743 referenceCount "1" @default.
- MAXO_0000743 hasDbXref "NCIT:C97936" @default.
- MAXO_0000743 hasExactSynonym "sulfonylurea antidiabetic agent therapy" @default.
- MAXO_0000743 hasExactSynonym "treatment with sulfonylurea agent" @default.
- MAXO_0000743 hasExactSynonym "treatment with sulfonylurea" @default.
- MAXO_0000743 type Class @default.
- MAXO_0000743 comment "Sulphonylurea antidiabetic agents bind to sulfonylurea receptor type 1 (SUR1), the subunit of ATP-sensitive inwardly-rectifier potassium (IKATP) channels on the membranes of pancreatic beta cells, thereby blocking the inward current flow (influx) of positively charged K+ ions into the cell. This results in tonic membrane depolarization, and induces a calcium ion influx through voltage-sensitive calcium channels; increased intracellular calcium ion levels trigger exocytosis of insulin-containing granules. This eventually induces secretion of insulin. The IKATP channels found in pancreatic islets are complexes of four IKATP 6.2 and four SUR1 subunits. In addition, some sulfonylureas of larger molecular size may increase the sensitivity of peripheral tissues to insulin mediated through peroxisome proliferator-activated receptor gamma (PPARgamma)." @default.
- MAXO_0000743 isDefinedBy maxo.owl @default.
- MAXO_0000743 label "sulfonylurea agent therapy" @default.
- MAXO_0000743 subClassOf BFO_0000001 @default.
- MAXO_0000743 subClassOf BFO_0000003 @default.
- MAXO_0000743 subClassOf BFO_0000015 @default.
- MAXO_0000743 subClassOf COB_0000034 @default.
- MAXO_0000743 subClassOf COB_0000082 @default.
- MAXO_0000743 subClassOf MAXO_0000001 @default.
- MAXO_0000743 subClassOf MAXO_0000002 @default.
- MAXO_0000743 subClassOf MAXO_0000058 @default.
- MAXO_0000743 subClassOf MAXO_0000175 @default.
- MAXO_0000743 subClassOf MAXO_0000257 @default.
- MAXO_0000743 subClassOf MAXO_0000258 @default.
- MAXO_0000743 subClassOf MAXO_0000572 @default.
- MAXO_0000743 subClassOf MAXO_0000743 @default.
- MAXO_0000743 category Entity @default.
- MAXO_0000743 category NamedThing @default.
- MAXO_0000743 category Occurrent @default.
- MAXO_0000743 category PhysicalEssenceOrOccurrent @default.