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- MONDO_0044248 IAO_0000115 "OBSOLETE. The sense of bitter taste is mediated by a group of bitter taste receptor proteins that reside on the surface of taste cells within the taste buds of the tongue. These proteins are 7-transmembrane domain, G protein-coupled receptors that are encoded by the TAS2R gene family (see TAS2R10; OMIM:604791), which contains at least 25 functional genes ({22:Kim et al., 2005}).nnHumans worldwide display a bimodality in sensitivity to the bitter taste of PTC, with approximately 75% of individuals perceiving it as intensely bitter, whereas the rest perceive it as tasteless. This difference has been the basis of study of taste perception in humans for over 70 years. {21:Kim and Drayna (2004)} provided an historical review of the subject.nnPropylthiouracil (PROP) and PTC are members of a class of compounds known as thioureas. The compounds carry the chemical group N-C=S, which is responsible for their characteristic bitter taste ({3:Bartoshuk et al., 1994}; {10:Drewnowski and Rock, 1995})." @default.
- MONDO_0044248 IAO_0000233 "https://github.com/monarch-initiative/mondo/issues/4521" @default.
- MONDO_0044248 normalizedInformationContent "100" @default.
- MONDO_0044248 referenceCount "1" @default.
- MONDO_0044248 hasDbXref "OMIM:171200" @default.
- MONDO_0044248 hasExactSynonym "phenylthiocarbamide tasting" @default.
- MONDO_0044248 hasRelatedSynonym "Phenylthiocarbamide tasting" @default.
- MONDO_0044248 hasRelatedSynonym "Propylthiouracil tasting" @default.
- MONDO_0044248 hasRelatedSynonym "THIOT" @default.
- MONDO_0044248 hasRelatedSynonym "prop tasting" @default.
- MONDO_0044248 hasRelatedSynonym "ptc tasting" @default.
- MONDO_0044248 hasRelatedSynonym "thiourea tasting" @default.
- MONDO_0044248 id "MONDO:0044248" @default.
- MONDO_0044248 type Class @default.
- MONDO_0044248 comment "Obsoleted as it represents a trait or is a legacy entry" @default.
- MONDO_0044248 isDefinedBy mondo.owl @default.
- MONDO_0044248 label "obsolete thiourea tasting" @default.
- MONDO_0044248 subClassOf MONDO_0044248 @default.
- MONDO_0044248 subClassOf Thing @default.
- MONDO_0044248 deprecated "true" @default.
- MONDO_0044248 exactMatch 171200 @default.