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- MONDO_0044259 IAO_0000115 "OBSOLETE. Two types of melanin, the red pheomelanin and the black eumelanin, are present in human skin. {22:Valverde et al. (1995)} noted that eumelanin is photoprotective, whereas pheomelanin may contribute to UV-induced skin damage because of its potential to generate free radicals in response to ultraviolet radiation. Individuals with red hair have a predominance of pheomelanin in hair and skin and/or a reduced ability to produce eumelanin, which may explain why they fail to tan and are at risk from ultraviolet radiation. In mammals, the relative proportions of pheomelanin and eumelanin are regulated by melanocyte-stimulating hormone (see OMIM:176830), which acts via its receptor (MC1R) on melanocytes to increase the synthesis of eumelanin, and also via the product of the agouti locus (AGTI; OMIM:600201), which antagonizes this action." @default.
- MONDO_0044259 IAO_0000233 "https://github.com/monarch-initiative/mondo/issues/4521" @default.
- MONDO_0044259 normalizedInformationContent "100" @default.
- MONDO_0044259 referenceCount "1" @default.
- MONDO_0044259 hasDbXref "OMIM:266300" @default.
- MONDO_0044259 hasExactSynonym "UV-induced skin damage" @default.
- MONDO_0044259 hasExactSynonym "skin/hair/eye pigmentation 2, blond hair/fair skin" @default.
- MONDO_0044259 hasExactSynonym "skin/hair/eye pigmentation 2, red hair/fair skin" @default.
- MONDO_0044259 hasRelatedSynonym "Blond hair/fair skin" @default.
- MONDO_0044259 hasRelatedSynonym "Red hair color" @default.
- MONDO_0044259 hasRelatedSynonym "Rha" @default.
- MONDO_0044259 hasRelatedSynonym "SHEP2" @default.
- MONDO_0044259 hasRelatedSynonym "UV-induced skin damage, susceptibility to" @default.
- MONDO_0044259 hasRelatedSynonym "hair color 2" @default.
- MONDO_0044259 hasRelatedSynonym "skin/hair/eye pigmentation, variation IN, 2" @default.
- MONDO_0044259 id "MONDO:0044259" @default.
- MONDO_0044259 type Class @default.
- MONDO_0044259 comment "Obsoleted as it represents a trait or is a legacy entry" @default.
- MONDO_0044259 isDefinedBy mondo.owl @default.
- MONDO_0044259 label "obsolete skin/hair/eye pigmentation, variation in, 2" @default.
- MONDO_0044259 subClassOf MONDO_0044259 @default.
- MONDO_0044259 subClassOf Thing @default.
- MONDO_0044259 deprecated "true" @default.
- MONDO_0044259 exactMatch 266300 @default.