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NCIT_C50977 IAO_0000115 "Human APEX1 wild -type allele is located within 14q11.2-q12 and is approximately 13 kb in length. This allele, which encodes DNA-(apurinic or apyrimidinic site) lyase protein, is involved in DNA repair and the maintenance of DNA integrity." @default.
NCIT_C50977 NCIT_NHC0 "C50977" @default.
NCIT_C50977 NCIT_P100 "107748" @default.
NCIT_C50977 NCIT_P101 "Escherichia coli exonuclease III Gene" @default.
NCIT_C50977 NCIT_P102 "NM_001641" @default.
NCIT_C50977 NCIT_P106 "Gene or Genome" @default.
NCIT_C50977 NCIT_P107 "APEX1 wt Allele" @default.
NCIT_C50977 NCIT_P108 "APEX1 wt Allele" @default.
NCIT_C50977 NCIT_P207 "C1705663" @default.
NCIT_C50977 NCIT_P211 "3'-5' exonuclease activity" @default.
NCIT_C50977 NCIT_P211 "DNA binding" @default.
NCIT_C50977 NCIT_P211 "DNA repair" @default.
NCIT_C50977 NCIT_P211 "DNA-(apurinic or apyrimidinic site) lyase activity" @default.
NCIT_C50977 NCIT_P211 "base-excision repair" @default.
NCIT_C50977 NCIT_P211 "endodeoxyribonuclease activity" @default.
NCIT_C50977 NCIT_P211 "endonuclease activity" @default.
NCIT_C50977 NCIT_P211 "nucleus" @default.
NCIT_C50977 NCIT_P211 "transcription co-activator activity" @default.
NCIT_C50977 NCIT_P211 "transcription co-repressor activity" @default.
NCIT_C50977 NCIT_P211 "transcription from Pol II promoter" @default.
NCIT_C50977 NCIT_P211 "uracil DNA N-glycosylase activity" @default.
NCIT_C50977 NCIT_P321 "328" @default.
NCIT_C50977 NCIT_P322 "CTRP" @default.
NCIT_C50977 NCIT_P366 "APEX1_wt_Allele" @default.
NCIT_C50977 NCIT_P96 "APEX Nuclease" @default.
NCIT_C50977 NCIT_P98 "APEX1 gene contains five exons spanning 2.64 kb; the first exon is untranslated. The 0.5 kb upstream DNA contains only a possible CCAAT box and no other regulatory sites or a TATA box. A potent activator of p53 protein, APE1 may protect against cell lethality and suppress mutations produced by spontaneous hydrolysis, by chemicals and radiation, or by DNA glycosylases that remove abnormal bases from DNA; abasic sites that can block DNA replication and cause mutations must be corrected to restore genetic integrity. A repressor of the PTH gene, APE binds to promoter negative Ca(2+)-response elements, which are also present in the APE1 gene." @default.
NCIT_C50977 NCIT_R130 NCIT_C17132 @default.
NCIT_C50977 NCIT_R130 NCIT_C19779 @default.
NCIT_C50977 NCIT_R130 NCIT_C20633 @default.
NCIT_C50977 NCIT_R130 NCIT_C39230 @default.
NCIT_C50977 NCIT_R130 NCIT_C39699 @default.
NCIT_C50977 NCIT_R130 NCIT_C39705 @default.
NCIT_C50977 NCIT_R130 NCIT_C91457 @default.
NCIT_C50977 NCIT_R130 NCIT_C91611 @default.
NCIT_C50977 NCIT_R145 NCIT_C12219 @default.
NCIT_C50977 NCIT_R145 NCIT_C21599 @default.
NCIT_C50977 NCIT_R145 NCIT_C40342 @default.
NCIT_C50977 NCIT_R145 NCIT_C41702 @default.
NCIT_C50977 NCIT_R145 NCIT_C42315 @default.
NCIT_C50977 NCIT_R145 NCIT_C64389 @default.
NCIT_C50977 NCIT_R37 NCIT_C16407 @default.
NCIT_C50977 NCIT_R37 NCIT_C16513 @default.
NCIT_C50977 NCIT_R37 NCIT_C16521 @default.
NCIT_C50977 NCIT_R37 NCIT_C16702 @default.
NCIT_C50977 NCIT_R37 NCIT_C17710 @default.
NCIT_C50977 NCIT_R37 NCIT_C17828 @default.
NCIT_C50977 NCIT_R37 NCIT_C18219 @default.
NCIT_C50977 NCIT_R37 NCIT_C18300 @default.
NCIT_C50977 NCIT_R37 NCIT_C18597 @default.
NCIT_C50977 NCIT_R37 NCIT_C19077 @default.
NCIT_C50977 NCIT_R37 NCIT_C19899 @default.
NCIT_C50977 NCIT_R37 NCIT_C19986 @default.
NCIT_C50977 NCIT_R37 NCIT_C20480 @default.
NCIT_C50977 NCIT_R37 NCIT_C21049 @default.
NCIT_C50977 NCIT_R37 NCIT_C21050 @default.
NCIT_C50977 NCIT_R37 NCIT_C21099 @default.
NCIT_C50977 NCIT_R37 NCIT_C28498 @default.
NCIT_C50977 NCIT_R37 NCIT_C40523 @default.
NCIT_C50977 NCIT_R37 NCIT_C41543 @default.
NCIT_C50977 NCIT_R40 NCIT_C12219 @default.
NCIT_C50977 NCIT_R40 NCIT_C13282 @default.
NCIT_C50977 NCIT_R40 NCIT_C13377 @default.
NCIT_C50977 NCIT_R40 NCIT_C13432 @default.
NCIT_C50977 NCIT_R40 NCIT_C13446 @default.
NCIT_C50977 NCIT_R40 NCIT_C13656 @default.
NCIT_C50977 NCIT_R40 NCIT_C14135 @default.
NCIT_C50977 NCIT_R40 NCIT_C32221 @default.
NCIT_C50977 NCIT_R40 NCIT_C34070 @default.
NCIT_C50977 NCIT_R41 NCIT_C14182 @default.
NCIT_C50977 NCIT_R41 NCIT_C14225 @default.
NCIT_C50977 NCIT_R41 NCIT_C14234 @default.
NCIT_C50977 NCIT_R41 NCIT_C14250 @default.
NCIT_C50977 NCIT_R41 NCIT_C14262 @default.
NCIT_C50977 NCIT_R41 NCIT_C14282 @default.
NCIT_C50977 NCIT_R41 NCIT_C25796 @default.
NCIT_C50977 NCIT_R41 NCIT_C79740 @default.
NCIT_C50977 normalizedInformationContent "100" @default.
NCIT_C50977 referenceCount "1" @default.
NCIT_C50977 hasExactSynonym "AP Endonuclease Class I Gene" @default.
NCIT_C50977 hasExactSynonym "AP Lyase Gene" @default.
NCIT_C50977 hasExactSynonym "APE Gene" @default.
NCIT_C50977 hasExactSynonym "APE1" @default.
NCIT_C50977 hasExactSynonym "APEN Gene" @default.
NCIT_C50977 hasExactSynonym "APEX Gene" @default.
NCIT_C50977 hasExactSynonym "APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 wt Allele" @default.
NCIT_C50977 hasExactSynonym "APEX Nuclease (Multifunctional DNA Repair Enzyme) Gene" @default.
NCIT_C50977 hasExactSynonym "APEX1 wt Allele" @default.
NCIT_C50977 hasExactSynonym "APX Gene" @default.
NCIT_C50977 hasExactSynonym "Apurinic Endonuclease Gene" @default.
NCIT_C50977 hasExactSynonym "Apurinic/Apyrimidinic Exonuclease Gene" @default.
NCIT_C50977 hasExactSynonym "DNA-(Apurinic or Apyrimidinic Site) Lyase Gene" @default.
NCIT_C50977 hasExactSynonym "Deoxyribonuclease (Apurinic or Apyrimidinic) Gene" @default.
NCIT_C50977 hasExactSynonym "HAP1 Gene" @default.
NCIT_C50977 hasExactSynonym "Human Apurinic Endonuclease 1 Gene" @default.
NCIT_C50977 hasExactSynonym "Multifunctional DNA Repair Enzyme Gene" @default.
NCIT_C50977 hasExactSynonym "REF-1 Gene" @default.
NCIT_C50977 hasExactSynonym "REF1 Gene" @default.
NCIT_C50977 hasExactSynonym "Redox Factor 1 Gene" @default.
NCIT_C50977 inSubset NCIT_C116977 @default.
NCIT_C50977 inSubset NCIT_C142799 @default.