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Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C51283> ?p ?o ?g. }

• NCIT_C51283 IAO_0000115 "Human MDM2 wild-type allele is located within 12q14.3-q15 and is approximately 32 kb in length. This allele, which encodes E3 ubiquitin-protein ligase Mdm2 protein, plays a role in the regulation of transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53 and diminish its tumor suppressor capability." @default.
• NCIT_C51283 NCIT_NHC0 "C51283" @default.
• NCIT_C51283 NCIT_P100 "164785" @default.
• NCIT_C51283 NCIT_P101 "MDM2/MDM4 Family" @default.
• NCIT_C51283 NCIT_P102 "NM_002392" @default.
• NCIT_C51283 NCIT_P106 "Gene or Genome" @default.
• NCIT_C51283 NCIT_P107 "MDM2 wt Allele" @default.
• NCIT_C51283 NCIT_P108 "MDM2 wt Allele" @default.
• NCIT_C51283 NCIT_P207 "C1708817" @default.
• NCIT_C51283 NCIT_P211 "negative regulation of cell proliferation" @default.
• NCIT_C51283 NCIT_P321 "4193" @default.
• NCIT_C51283 NCIT_P322 "CTRP" @default.
• NCIT_C51283 NCIT_P366 "MDM2_wt_Allele" @default.
• NCIT_C51283 NCIT_P96 "MDM2 Protein" @default.
• NCIT_C51283 NCIT_P98 "Flanked by microsatellites D12S80 and D12S83, human MDM2 Gene (MDM2/MDM4 family) at 12q14.3-q15 encodes a 90 kD ubiquitin ligase E3 phosphoprotein that complexes with p53 in S/G2/M, targeting its degradation and inhibiting p53-mediated gene transactivation. The 25 kb murine gene contains at least twelve exons and MDM2 expression is regulated by the RAS/MAPK pathway. Upon DNA damage, phosphorylation of p53 suppresses interaction with MDM2 and p14(ARF) inhibits MDM2 activity. Interaction with MDM2 inhibits RB protein. MDM2 amplification is found in some cancers and may lead to escape from p53-regulation of growth control." @default.
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