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• NCIT_C53098 IAO_0000115 "Human NFKB2 wild-type allele is located in the vicinity of 10q24 and is approximately 8 kb in length. This allele, which encodes nuclear factor NF-kappa-B p100 subunit protein, is involved in the modulation of transcription by RNA polymerase II. A variety of leukemias and lymphomas are associated with translocations t(10;14)(q24;q11) of the gene and the T-cell receptor alpha or delta locus, or t(10;14)(q24;q32) of this gene and the IGHA1 locus." @default.
• NCIT_C53098 NCIT_NHC0 "C53098" @default.
• NCIT_C53098 NCIT_P100 "164012" @default.
• NCIT_C53098 NCIT_P101 "NFKB Family" @default.
• NCIT_C53098 NCIT_P102 "NM_002502" @default.
• NCIT_C53098 NCIT_P106 "Gene or Genome" @default.
• NCIT_C53098 NCIT_P107 "NFKB2 wt Allele" @default.
• NCIT_C53098 NCIT_P108 "NFKB2 wt Allele" @default.
• NCIT_C53098 NCIT_P207 "C1704849" @default.
• NCIT_C53098 NCIT_P211 "transcription co-activator activity" @default.
• NCIT_C53098 NCIT_P211 "transcription factor activity" @default.
• NCIT_C53098 NCIT_P321 "4791" @default.
• NCIT_C53098 NCIT_P322 "CTRP" @default.
• NCIT_C53098 NCIT_P366 "NFKB2_wt_Allele" @default.
• NCIT_C53098 NCIT_P96 "NF-Kappa B p49/p100" @default.
• NCIT_C53098 NCIT_P98 "The NFKB2 gene product can be processed to yield three different polypeptides, designated p100, p52 and p49. The unprocessed p100 polypeptide is a minor form that facilitates cytoplasmic retention of complexed NF-kappa-B proteins. In a regulated cotranslational event, processing of p100 yields the predominant polypeptide p52, which translocates to the nucleus and binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in the immune response and acute phase reactions. The p100 polypeptide can be alternatively processed to yield the p49 polypeptide, which also is found in NF-kappa-B protein complexes, and which stimulates the HIV enhancer in synergy with the RELA gene product, transcription factor p65 (GeneCards)." @default.
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• NCIT_C53098 hasExactSynonym "CVID10" @default.
• NCIT_C53098 hasExactSynonym "H2TF1" @default.
• NCIT_C53098 hasExactSynonym "LYT-10" @default.
• NCIT_C53098 hasExactSynonym "LYT10" @default.
• NCIT_C53098 hasExactSynonym "NF-kB2" @default.
• NCIT_C53098 hasExactSynonym "NFKB2 wt Allele" @default.
• NCIT_C53098 hasExactSynonym "Nuclear Factor Kappa B Subunit 2 wt Allele" @default.
• NCIT_C53098 hasExactSynonym "Nuclear Factor of Kappa Light Chain Gene Enhancer in B-cells 2 Gene" @default.
• NCIT_C53098 hasExactSynonym "Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells 2 (p49/p100) Gene" @default.
• NCIT_C53098 hasExactSynonym "p100" @default.
• NCIT_C53098 hasExactSynonym "p49/p100" @default.
• NCIT_C53098 hasExactSynonym "p52" @default.
• NCIT_C53098 inSubset NCIT_C116977 @default.
• NCIT_C53098 inSubset NCIT_C142799 @default.
• NCIT_C53098 inSubset NCIT_C142800 @default.
• NCIT_C53098 type Class @default.
• NCIT_C53098 isDefinedBy ncit.owl @default.

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