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- NCIT_C54369 IAO_0000115 "Human BCAR3 wild-type allele is located in the vicinity of 1p22.1 and is approximately 285 kb in length. This allele, which encodes breast cancer anti-estrogen resistance protein 3, plays a role in cellular proliferation and tyrosine kinase signal transduction." @default.
- NCIT_C54369 NCIT_NHC0 "C54369" @default.
- NCIT_C54369 NCIT_P100 "604704" @default.
- NCIT_C54369 NCIT_P101 "CDC48 (Yeast)" @default.
- NCIT_C54369 NCIT_P102 "NM_003567" @default.
- NCIT_C54369 NCIT_P106 "Gene or Genome" @default.
- NCIT_C54369 NCIT_P108 "BCAR3 wt Allele" @default.
- NCIT_C54369 NCIT_P207 "C1705392" @default.
- NCIT_C54369 NCIT_P211 "drug resistance" @default.
- NCIT_C54369 NCIT_P211 "regulation of cell cycle" @default.
- NCIT_C54369 NCIT_P211 "signal transduction" @default.
- NCIT_C54369 NCIT_P321 "8412" @default.
- NCIT_C54369 NCIT_P366 "BCAR3_wt_Allele" @default.
- NCIT_C54369 NCIT_P96 "Breast Cancer Anti-Estrogen Resistance 3" @default.
- NCIT_C54369 NCIT_P98 "Human BCAR3 Gene encodes a 92 kD 825-amino acid protein that contains a putative SH2 domain, a hallmark of tyrosine kinase signaling molecules, and sequences homologous to CDC48 (Yeast). Abundant expression of a 3.4 kb transcript is seen in heart, placenta, skeletal muscle, spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and several cancer cell lines, but not in nonmalignant breast tissue. A 6 kb transcript is also detected in skeletal muscle and heart. NSP2 induces anti-estrogen resistance in estrogen-dependent breast tumors. BRCA3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells." @default.
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- NCIT_C54369 hasExactSynonym "BCAR3 wt Allele" @default.
- NCIT_C54369 hasExactSynonym "BCAR3" @default.
- NCIT_C54369 hasExactSynonym "Breast Cancer Anti-Estrogen Resistance 3 wt Allele" @default.
- NCIT_C54369 hasExactSynonym "NSP2" @default.
- NCIT_C54369 hasExactSynonym "SH2D3B" @default.
- NCIT_C54369 type Class @default.
- NCIT_C54369 isDefinedBy ncit.owl @default.
- NCIT_C54369 label "BCAR3 wt Allele" @default.
- NCIT_C54369 subClassOf NCIT_C16612 @default.
- NCIT_C54369 subClassOf NCIT_C20770 @default.
- NCIT_C54369 subClassOf NCIT_C20917 @default.
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